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I-Oxynitrilases (HNL)
Mayelana ne-oxynitrilases
ES-HNLs: I-enzyme yekilasi eyenza ngokuzenzakalelayo ukungezwa kwe-HCN kuma-aldehydes (ketones) ukuze kutholwe u-R noma u-S ohlobo lwe-cyanide alcohols, olungaguqulelwa kalula lube izinhlobo eziningi zezidakamizwa noma izidakamizwa eziphakathi ngendlela yamakhemikhali.
Kunezinhlobo ezingama-29 zemikhiqizo ye-oxynitrilase (Inombolo njengokuthi ES-HNL-101～ES-HNL-129) ethuthukiswe yi-SyncoZymes.I-SZ-HNL iyithuluzi eliwusizo ku-regio- kanye ne-stereo- selective synthesis ye- (R) -cyanohydrins noma (S) -cyanohydrins evela ezinhlobonhlobo zama-aldehydes anuka, aliphatic kanye ne-heterocyclic noma ngisho nama-ketone.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Nitro reductase (NTR)
Mayelana ne-nitro reductase
Ama-ES-NTRs: Ama-flavoenzymes enza ukuncipha okuncike ku-NAD(P)H kwamaqembu e-nitro kumakhompiyutha e-nitroaromatic kanye ne-nitroheterocyclic kuya ku-hydroxylamino kanye/noma kokuphuma kokunye kwe-amino.Asetshenziswa kakhulu ekuhlanganiseni okuphilayo kwe-hydroxylamine enephunga elimnandi ne-amine enuka kamnandi, ukwelapha isimila, ukutholwa kwezinto eziphilayo kanye nokucekelwa phansi kwezinto ezingcolisa imvelo.Kunezinhlobo ezingu-12 zemikhiqizo ye-Nitro reductase (NTR) (Inombolo njengokuthi ES-NTR-101~ES-NTR-112) eyakhiwe yi-SyncoZymes.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Aldolase (DERA)
I-ES-DERAs: Ingakwazi ukwenza ngempumelelo ukungezwa kwe-stereoselective kwama-ketones abanikeli kuma-aldehydes e-receptor.Ngaphezu kwalokho, ukusabela kungenziwa ngesisombululo samanzi se-pH engathathi hlangothi ngaphandle kwezinyathelo ezikhethekile zokuzivikela.Ziyingxenye yekilasi I aldolase, eyenza isisekelo sika-Shiff kunqubo ye-catalytic.I-substrate iboshwe ngokuhlanganyela neqembu le-amino lesayithi elisebenzayo ukuze kuqalwe ukuphuka nokwakheka kwebhondi.Umehluko phakathi kwama-DERA namanye ama-aldolase ukuthi ama-substrates awadalayo angama-aldehydes futhi angabhekana nokujiya kwe-aldehydes okuqhubekayo.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Cytochrome P450 monooxygenase (CYP)
Mayelana ne-CYP
I-ES-CYPs: Isigaba sama-enzyme e-redox ane-mercaptan-heme njengesikhungo esisebenzayo sokugqugquzela ukudluliswa komoyampilo.Ziyi-oxygenases yokugcina futhi idinga i-heme ukuze isebenze umoya-mpilo.
I-Cytochrome P450 monooxygenase yenza i-oxidation, i-epoxidation kanye ne-hydroxylation ye-alkyl, i-hydroxylation kanye ne-oxidation ye-ammonia, i-oxidation yesibabule, i-dealkylation (i-oksijeni, isulfure, i-ammonia), i-oxidative dehydrogenation, deamination and dehalogenation.
Kunezinhlobo ezingu-8 zemikhiqizo ye-cytochrome P450 monooxygenase (Inombolo njengokuthi ES-CYP-101～ES-CYP-108) ethuthukiswe yi-SyncoZymes.Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Alcohol oxidase (AOX)
Mayelana ne-alcohol oxidase
I-ES-AOXs: Lawa ma-enzyme ayakwazi ukwenza i-oxidation yama-alcohols anamafutha noma ama-aryl-alcohols akhe ama-aldehydes.Basebenzisa i-oxygen yamangqamuzana kodwa ayidingi i-cofactor eyengeziwe, kanye ne-hydrogen peroxide ekhiqizwa.
Kunezinhlobo ezingu-6 zemikhiqizo ye-alcohol oxidases (Inombolo njengokuthi ES-AOX-101~ES-AOX-106) ethuthukiswe yi-SyncoZymes.I-ES-AOX101 kanye ne-ES-AOX102 bakhetha ama-aliphatic alcohol substrates, i-ES-AOX103~ ES-AOX105 ikhetha ama-alcohol substrates anephunga elimnandi, kanti i-ES-AOX106 i-cholesterol oxidase.I-SZ-AOX iyithuluzi eliwusizo lokwenza i-oxidation yotshwala obunamafutha noma i-aryl-alcohols ukukhiqiza ama-aldehydes.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-D-Amino acid dehydrogenase (D-AADH)
Mayelana ne-D-Amino acid dehydrogenase
I-ES-D-AADH (D-Amino acid dehydrogenase): i-enzyme enganciphisa i-2-keto acid ibe i-D-amino acid ehambisanayo.Ukusabela kudinga i-NADP(H) kanye nomnikezeli we-ammonia we-inorganic (njenge-ammonia noma i-ammonium ion).Kunezinhlobo ezingu-17 ze-D-amino acid dehydrogenases (Inombolo njengokuthi ES-DAADH-101~ ES-DAADH-117) ethuthukiswe yi-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Esterase&Lipase (PLE&CALB)
Mayelana ne-Esterase&Lipase
ES-PLEs: Ikilasi lama-hydrolases abangela ukwakheka nokuphuka kwamabhondi e-ester.Bangabamba iqhaza ezinhlotsheni eziningi zokusabela kwamakhemikhali ezinto eziphilayo, njenge-esterification, i-transesterification kanye ne-hydrolysis.Zisetshenziswa kakhulu emikhakheni eminingi efana nokucubungula ukudla, imboni yamakhemikhali, i-biomedicine, imithi ye-chiral kanye nokwelashwa kwemvelo.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Epoxide hydrolase (EH)
Mayelana ne-epoxide hydrolase
I-EH i-ether hydrolase eyenza i-stereoelective hydrolysis yama-racemic epoxides ukukhiqiza i-1, 2-diol kanye nama-epoxide asebenzayo, angasetshenziselwa ukulungiswa kwe-chiral yama-epoxides noma ukulungiswa kwama-chiral diols.Asetshenziswa kakhulu kwezokwelapha nakweminye imikhakha.Kunezinhlobo ezi-3 zemikhiqizo ye-epoxide hydrolases (Inombolo njengokuthi ES-EH-101～ES-EH-103) ethuthukiswe yi-SyncoZymes.I-ES-EH iyithuluzi eliwusizo lokugqugquzela ukuhlanganiswa kotshwala be-chiral ngokusebenzisa i-stereoelective hydrolysis yama-aliphatic and aromatics epoxides.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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Yenza i-dehydrogenase (FDH)
Mayelana ne-Formate dehydrogenase
I-ES-FDH (Formate dehydrogenase): I-FDH yenza i-dehydrogenation ye-ammonium formate ikhiqize i-carbon dioxide ne-ammonia, futhi yehlise i-NAD ibe yi-NADH nge-NAD njengesamukeli sama-electron.I-FDH ivame ukusetshenziselwa ukuvuselelwa kwe-coenzyme NADH.Kunezinhlobo ezi-4 zemikhiqizo ye-enzyme ye-FDH (ES-FDH-101~ES-FDH-104) eyakhiwe yi-SyncoZymes, phakathi kwayo i-ES-FDH102 inomsebenzi ophezulu kakhulu futhi iyi-FDH enconywa kakhulu.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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IGlucose dehydrogenase (GDH)
Mayelana neGlucose dehydrogenase
I-ES-GDH (I-Glucose dehydrogenase): I-GDH yenza i-dehydrogenation ye-glucose ikhiqize i-gluconic acid (lactone), futhi yehlise i-NAD(P)+ ibe yi-NAD(P)H, nge-NAD(P)+ njenge-electron receptor.I-GDH ivame ukusetshenziselwa ukuvuselelwa kwe-coenzyme NAD(P)H emikhakheni ye-biocatalysis nenye i-enzyme eyinhloko.Kunezinhlobo ezingu-10 zemikhiqizo ye-enzyme ye-GDH (ES-GDH-101~ES-GDH-110) eyakhiwe yi-SyncoZymes, phakathi kwayo i-ES-GDH110 inomsebenzi ophezulu kakhulu futhi iyi-GDH enconywa kakhulu.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Monoamine oxidase (MAO)
Mayelana ne-Monoamine oxidase
I-ES-MAO(Monoamine oxidase): I-MAO yenza i-oxidative deamination ye-monoamines ikhiqize i-hydrogen peroxide, i-ammonia kanye nama-aldehyde ahambisanayo.Enqubweni ye-catalytic, umoya-mpilo uyadingeka njenge-oxidant.Kunezinhlobo eziyisi-6 zemikhiqizo ye-enzyme ye-MAO (Inombolo njenge-ES-MAO-101～ES-MAO-106) eyakhiwe yi-SyncoZymes, engasetshenziswa ekuqedeni i-oxidative yezinhlanganisela ze-monoamine.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Lactate Dehydrogenase (LDH)
Mayelana ne-Lactate dehydrogenase
Kunohlobo olungu-1 lomkhiqizo we-enzyme ye-LDH (Inombolo njenge-ES-LDH) eyakhiwe yi-SyncoZymes.I-LDH ingabangela ukuncipha kwe-pyruvate ku-L-lactic acid, noma ukunciphisa amanye ama-α-keto acid afanayo.Enqubweni ye-catalysis, i-NADH iyadingeka njengesithuthi se-hydrogen.
Uhlobo lokusabela lwe-lactate dehydrogenasecatalytic
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
