I-Aldolase (DERA)

Incazelo emfushane:

I-ES-DERAs: Ingakwazi ukwenza ngempumelelo ukungezwa kwe-stereoselective kwama-ketones abanikeli kuma-aldehydes e-receptor.Ngaphezu kwalokho, ukusabela kungenziwa ngesisombululo samanzi se-pH engathathi hlangothi ngaphandle kwezinyathelo ezikhethekile zokuzivikela.Ziyingxenye yekilasi I aldolase, eyenza isisekelo sika-Shiff kunqubo ye-catalytic.I-substrate iboshwe ngokuhlanganyela neqembu le-amino lesayithi elisebenzayo ukuze kuqalwe ukuphuka nokwakheka kwebhondi.Umehluko phakathi kwama-DERA namanye ama-aldolase ukuthi ama-substrates awadalayo angama-aldehydes futhi angabhekana nokujiya kwe-aldehydes okuqhubekayo.

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I-imeyili:lchen@syncozymes.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Mayelana ne-Aldolase:

Kunezinhlobo ezingu-8 zemikhiqizo ye-aldolase (Inombolo njengokuthi ES-DERA-101～ES-DERA-108) eyakhiwe i-SyncoZymes.I-SZ-DERA iyithuluzi eliwusizo lokugqugquzela ukwakheka kwebhondi ye-carbon-carbon enantioselective, ekhiqiza kufika kuzikhungo ezimbili ze-chiral ngaphansi kwezimo zokusabela okuncane.

Uhlobo lokusabela kwe-Catalytic:

Indlela ye-Catalytic:

Ulwazi Lomkhiqizo:

Ama-enzyme	Ikhodi Yomkhiqizo	Ukucaciswa
I-Enzyme Powder	ES-DERA-101~ ES-DERA-108	isethi ye-8 Aldolase, 50 mg ngayinye 8 izinto * 50mg / into, noma elinye inani
Ikhithi Yokuhlola (SynKit)	ES-DERA-800	isethi 8 Aldolase, 1 mg ngayinye 8 izinto * 1mg / into

Izinzuzo:

★ I-spectrum ye-substrate ebanzi.
★ ukuguqulwa okuphezulu.
★ Imikhiqizo engaphansi.
★ Izimo zokusabela ezithambile.
★ Ayinandaba nemvelo.

Imiyalo yokusebenzisa:

➢ Ngokuvamile, isistimu yokusabela kufanele ifake i-substrate, isixazululo se-buffer (i-pH yokusabela ekahle) kanye ne-ES-DERA.
➢ Zonke izinhlobo ze-ES-DERA ezihambisana nezimo zokusabela ezifanele kufanele zifundwe ngazodwana.
➢ I-ES-DERA kufanele yengezwe okokugcina ohlelweni lokusabela ukuze kugcinwe umsebenzi.
➢ I-Substrate egxilile ephezulu noma umkhiqizo onawo ungase uvimbele umsebenzi we-ES-DERA.Kodwa-ke, ukuvimbela kungakhululwa ngokungezwa kwe-batch ye-substrate.

Izibonelo Zohlelo Lokusebenza:

Isibonelo 1⁽¹⁾:

Isitoreji:

Gcina iminyaka emi-2 ngaphansi -20 ℃.

Qaphela:

Ungalokothi uthintane nezimo eziyingozi kakhulu ezifana nalezi: izinga lokushisa eliphezulu, i-pH ephezulu/ephansi kanye ne-solvent ephilayo egxilile.