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I-Ketoreductase (KRED)
Mayelana ne-Ketoreductase
Ama-Enzymes: Ama-macromolecular biological catalysts, ama-enzyme amaningi angamaprotheni.
I-Ketoreductase: Ebuye ibizwe ngokuthi “i-Carbonyl reductase”, ama-enzyme akhanga ukusabela kwe-redox okubuyisela emuva phakathi kwe-aldehydes / ketones notshwala, futhi adinga ama-coenzymes njengesidluliseli se-H njenge-NADH noma i-NADPH.Kunezigaba ezintathu eziyinhloko ze-KRED: I-Dehydrogenase / Reductases (SDRs), i-Medium-chain Dehydrogenases / Reductases (MDRs), kanye ne-Aldo-KetoReductases (AKRs).Imisebenzi ye-catalytic yalezi zintathu ziyefana, kodwa ukwakheka nezakhiwo kuhluke kakhulu.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Transaminase (ATA)
Mayelana ne-transaminase
I-ATA evela ku-SyncoZymes: Kunezinhlobo ezingu-66 zemikhiqizo ye-enzyme ye-ATA (Inombolo njengokuthi ES-ATA-101~ES-ATA-166) ithuthukiswe i-SyncoZymes.I-SZ-ATA iyithuluzi eliwusizo lokwenza i-regio- kanye ne-stereoelective synthesis yama-chiral amines, ama-amino acid kanye nokuphuma kwawo okuvela ezinhlobonhlobo zama-ketoacids aliphatic kanye nephunga elimnandi, ama-aldehydes, ama-ketone nama-ketose.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Nitrilase (NIT)
Mayelana ne-Nitrilase
I-ES-NITs: Guqula ngokuqondile iqembu le-cyanide libe yiqembu le-carboxyl, ukulungiselela i-carboxylic acid, esetshenziswa kabanzi kwezokwelapha, ukuvikelwa kwemvelo, imboni yamakhemikhali, izithasiselo zokudla, izindwangu, ukukhiqizwa kwezolimo neminye imikhakha.
Kunezinhlobo ezingu-40 zemikhiqizo ye-Nitrilase(NIT) (Inombolo njenge-ES-NIT-101~ES-NIT-140) eyakhiwe ngabakwa-SyncoZymes.I-ES-NIT iyithuluzi eliwusizo lokwenza ukuhlanganiswa kwe-chiral carboxylic acid ngokusebenzisa i-regio- kanye ne-stereoselective hydrolysis yohlu olubanzi lwe-aliphatic ne-aromatic nitriles.Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Nitrile hydratase (NHT)
Mayelana ne-ES-NHTs
I-ES-NHTs: isigaba se-metalloenzyme, ekhetha ngokukhetha i-nitriles ku-amide eyinhloko ehambisanayo.Asetshenziswa kabanzi hhayi kuphela ukuhlanganiswa kwama-amino acid, ama-amide, ama-carboxylic acid kanye nokuphuma kwawo, kodwa futhi nasekulungiseleleni izidakamizwa ze-chiral.Kunezinhlobo ezingama-24 zama-nitrile hydratases athuthukiswe yi-SyncoZymes (Inombolo njenge-ES-NHT-101～ES-NHT-124).
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Amidase (AMD)
I-AMD evela ku-SyncoZymes: Kunezinhlobo ezingu-19 zemikhiqizo ye-enzyme ye-AMD (Inombolo njenge-ES-AMD-101~ES-AMD-119) eyakhiwe yi-SyncoZymes.I-SZ-AMD iyithuluzi eliwusizo lokwenza i-regio- kanye ne-stereoelective synthesis yama-chiral carboxylic acid kanye nokuphuma kwawo okuvela ezinhlobonhlobo zama-amide aliphatic kanye nephunga elimnandi.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Ene reductase (ERED)
Mayelana ne-ene reductase
I-ES-EREDs: Eyomndeni wama-enzyme aphuzi amadala anciphisa ngokukhetha i-C=C ku-α, i-β -unsaturated compounds namaqembu abamba i-electron.Zisetshenziswa kabanzi ekutadisheni kokuphuma kwe-amino acid, izinto ezisebenzayo, i-intermediate yezemithi, izinongo namabhulokhi e-chiral.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Oxynitrilases (HNL)
Mayelana ne-oxynitrilases
ES-HNLs: I-enzyme yekilasi eyenza ngokuzenzakalelayo ukungezwa kwe-HCN kuma-aldehydes (ketones) ukuze kutholwe u-R noma u-S ohlobo lwe-cyanide alcohols, olungaguqulelwa kalula lube izinhlobo eziningi zezidakamizwa noma izidakamizwa eziphakathi ngendlela yamakhemikhali.
Kunezinhlobo ezingama-29 zemikhiqizo ye-oxynitrilase (Inombolo njengokuthi ES-HNL-101～ES-HNL-129) ethuthukiswe yi-SyncoZymes.I-SZ-HNL iyithuluzi eliwusizo ku-regio- kanye ne-stereo- selective synthesis ye- (R) -cyanohydrins noma (S) -cyanohydrins evela ezinhlobonhlobo zama-aldehydes anuka, aliphatic kanye ne-heterocyclic noma ngisho nama-ketone.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Nitro reductase (NTR)
Mayelana ne-nitro reductase
Ama-ES-NTRs: Ama-flavoenzymes enza ukuncipha okuncike ku-NAD(P)H kwamaqembu e-nitro kumakhompiyutha e-nitroaromatic kanye ne-nitroheterocyclic kuya ku-hydroxylamino kanye/noma kokuphuma kokunye kwe-amino.Asetshenziswa kakhulu ekuhlanganiseni okuphilayo kwe-hydroxylamine enephunga elimnandi ne-amine enuka kamnandi, ukwelapha isimila, ukutholwa kwezinto eziphilayo kanye nokucekelwa phansi kwezinto ezingcolisa imvelo.Kunezinhlobo ezingu-12 zemikhiqizo ye-Nitro reductase (NTR) (Inombolo njengokuthi ES-NTR-101~ES-NTR-112) eyakhiwe yi-SyncoZymes.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Aldolase (DERA)
I-ES-DERAs: Ingakwazi ukwenza ngempumelelo ukungezwa kwe-stereoselective kwama-ketones abanikeli kuma-aldehydes e-receptor.Ngaphezu kwalokho, ukusabela kungenziwa ngesisombululo samanzi se-pH engathathi hlangothi ngaphandle kwezinyathelo ezikhethekile zokuzivikela.Ziyingxenye yekilasi I aldolase, eyenza isisekelo sika-Shiff kunqubo ye-catalytic.I-substrate iboshwe ngokuhlanganyela neqembu le-amino lesayithi elisebenzayo ukuze kuqalwe ukuphuka nokwakheka kwebhondi.Umehluko phakathi kwama-DERA namanye ama-aldolase ukuthi ama-substrates awadalayo angama-aldehydes futhi angabhekana nokujiya kwe-aldehydes okuqhubekayo.
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Cytochrome P450 monooxygenase (CYP)
Mayelana ne-CYP
I-ES-CYPs: Isigaba sama-enzyme e-redox ane-mercaptan-heme njengesikhungo esisebenzayo sokugqugquzela ukudluliswa komoyampilo.Ziyi-oxygenases yokugcina futhi idinga i-heme ukuze isebenze umoya-mpilo.
I-Cytochrome P450 monooxygenase yenza i-oxidation, i-epoxidation kanye ne-hydroxylation ye-alkyl, i-hydroxylation kanye ne-oxidation ye-ammonia, i-oxidation yesibabule, i-dealkylation (i-oksijeni, isulfure, i-ammonia), i-oxidative dehydrogenation, deamination and dehalogenation.
Kunezinhlobo ezingu-8 zemikhiqizo ye-cytochrome P450 monooxygenase (Inombolo njengokuthi ES-CYP-101～ES-CYP-108) ethuthukiswe yi-SyncoZymes.Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-Alcohol oxidase (AOX)
Mayelana ne-alcohol oxidase
I-ES-AOXs: Lawa ma-enzyme ayakwazi ukwenza i-oxidation yama-alcohols anamafutha noma ama-aryl-alcohols akhe ama-aldehydes.Basebenzisa i-oxygen yamangqamuzana kodwa ayidingi i-cofactor eyengeziwe, kanye ne-hydrogen peroxide ekhiqizwa.
Kunezinhlobo ezingu-6 zemikhiqizo ye-alcohol oxidases (Inombolo njengokuthi ES-AOX-101~ES-AOX-106) ethuthukiswe yi-SyncoZymes.I-ES-AOX101 kanye ne-ES-AOX102 bakhetha ama-aliphatic alcohol substrates, i-ES-AOX103~ ES-AOX105 ikhetha ama-alcohol substrates anephunga elimnandi, kanti i-ES-AOX106 i-cholesterol oxidase.I-SZ-AOX iyithuluzi eliwusizo lokwenza i-oxidation yotshwala obunamafutha noma i-aryl-alcohols ukukhiqiza ama-aldehydes.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
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I-D-Amino acid dehydrogenase (D-AADH)
Mayelana ne-D-Amino acid dehydrogenase
I-ES-D-AADH (D-Amino acid dehydrogenase): i-enzyme enganciphisa i-2-keto acid ibe i-D-amino acid ehambisanayo.Ukusabela kudinga i-NADP(H) kanye nomnikezeli we-ammonia we-inorganic (njenge-ammonia noma i-ammonium ion).Kunezinhlobo ezingu-17 ze-D-amino acid dehydrogenases (Inombolo njengokuthi ES-DAADH-101~ ES-DAADH-117) ethuthukiswe yi-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
