Abakhiqizi Bemikhiqizo - Ifektri Yemikhiqizo YaseShayina Nabahlinzeki

I-Phosphokinase (PKase)

Mayelana ne-Phosphokinase

I-ES-PKase (i-Phosphokinase): ivuselela ukudluliselwa kwamaqembu e-phosphate ku-ATP kwamanye ama-compounds. Iphinde ivuselele ukudluliselwa kwamaqembu e-phosphate kwamanye ama-nucleoside e-triphosphate ngezinye izikhathi. Ama-kinase amaningi adinga ama-ion ensimbi ahlukene ukuze ahlanganyele ekusabeleni (ngokuvamile i-Mg2+). Kunezinhlobo ezingu-21 zemikhiqizo ye-enzyme ye-PKase (Inombolo njenge-ES-PKase101~ ES-PKase-121) eyenziwe yi-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Cyclooxygenase (COX)

Mayelana ne-Cyclooxygenase

I-ES-COX (i-Cyclooxygenase): ivuselela ukuguqulwa kwezibopho ze-C=C zibe yi-epoxide. Kunezinhlobo ezingu-11 zemikhiqizo ye-enzyme ye-COX (Inombolo njenge-ES-COX101~ ES-COX-111) eyenziwe yi-SyncoZymes. Ngokwendlela ehlukene yokucubungula, i-COX ye-SyncoZymes ihlukaniswe yi-haloperoxidase kanye ne-styrene monooxygenase. I-ES-COX101, 102, 107-111 ingeye-haloperoxidase, kanti i-ES-COX103-106 ingeye-styrene monooxygenase.

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Cyclohexanone monooxygenase (CHMO)

Mayelana ne-Cyclohexanone monooxygenase

I-ES-CHMO (i-Cyclohexanone monooxygenase): i-Baeyer Villiger monooxygenase (BVMO) ene-cyclohexanone njenge-substrate, ingaxuba i-cyclohexanone ibe yi-cyclohexanol isebenzisa i-oxygen.

Luhlobo lwe-enzyme encike ku-flavin. I-flavin e-oxidized incishiswa ibe yi-flavin ngomjikelezo wokunciphisa i-coenzyme II (NADPH) ukuze kutholakale i-oxidation elandelayo. Ngakho-ke, i-cofactor NADPH iyadingeka emjikelezweni we-flavin. Kukhona uhlobo olulodwa kuphela lomkhiqizo we-enzyme ye-CHMO (Inombolo njenge-ES-CHMO101) eyakhiwa yi-SyncoZymes, engasetshenziswa ukuxubha i-cyclohexanone ibe yi-cyclohexanone.

Uhlobo lokusabela kwe-Catalytic:

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Carboxylic acid reductase (CAR)

Mayelana ne-Carboxylic acid reductase

I-ES-CAR (i-Carboxylic acid reductase): ivuselela ukwehla kweqembu le-carboxyl libe yiqembu le-aldehyde. Enqubweni yokuvuselela, ukusebenza kwe-ATP kanye ne-coenzyme NADPH kuyadingeka njengabathuthi be-hydrogen. Kunezinhlobo ezimbili zemikhiqizo ye-enzyme ye-CAR (Inombolo njenge-ES-CAR101~ ES-CAR-102) eyenziwe yi-SyncoZymes.

Uhlobo lokusabela kwe-Catalytic:

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Eluxadoline Intermediate methyl 5-(((S)-2-((tert-butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)-N-((S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl)propanamido)methyl)-2-methoxybenzoate

Inombolo yekhathalogi SZ-2078

I-CAS: 1137026-67-5

Ubumsulwa: 99%

Ukusetshenziswa kwe-Eluxadoline

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Eluxadoline Intermediate (S)-Methyl 2-Methoxy-5-((1-(4-phenyl-1H-imidazol-2-yl)ethylamino)methyl)benzoate

Inombolo yekhathalogi SZ-2077

I-CAS: 1391712-57-4

Ubumsulwa: 99%

Ukusetshenziswa kwe-Eluxadoline

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Adapalene Intermediate 1-(5-bromo-2-methoxy-phenyl)adamantane

Inombolo yekhathalogi SZ-1559

I-CAS: 104224-63-7

Ubumsulwa: 99%

Ukusetshenziswa kwe-Adpalene

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Eluxadoline Intermediate (S)-Methyl 2-Methoxy-5-((1-(4-phenyl-1H-imidazol-2-yl)ethylamino)methyl)benzoate i-oxalic acid

Inombolo yekhathalogi SZ-2077

I-CAS: 2046303-09-5

Ubumsulwa: 99%

Ukusetshenziswa kwe-Eluxadoline

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Ibrutinib Intermediate (S)-1-Boc-3-hydroxypiperidine

Inombolo yekhathalogi SZ-1527

I-CAS: 143900-44-1

Ubumsulwa: 99%

Ukusetshenziswa kwe-Ibrutinib

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Ibrutinib Intermediate 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Inombolo yekhathalogi SZ-2028

I-CAS: 330786-24-8

Ubumsulwa: 99%

Ukusetshenziswa kwe-Ibrutinib

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Ibrutinib Intermediate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Inombolo yekhathalogi SZ-2028-4

I-CAS: 330792-70-6

Ubumsulwa: 99%

Ukusetshenziswa 25kg/umgqomo

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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I-Phenylalanine dehydrogenase (PDH)

Mayelana ne-Phenylalanine dehydrogenase

I-ES-PDH: Uhlobo lwe-oxidoreductase. Ukusabela okuhle kungavuselela ukususwa kwe-oxidative kwe-L phenylalanine salt lapho kukhona i-NAD ukuze kukhiqizwe usawoti we-phenylpyruvate, kanti ukusabela okuphambene nakho kungavuselela ukwenziwa kwe-amino acid salt ehambisanayo kusuka kusawoti we-phenylpyruvate. Ama-Syncozymes athuthukise izinto ezingu-8 ze-phenylalanine dehydrogenase (ezinenombolo ze-ES-PDH-101~ES-PDH-108). I-ES-PDH ingasetshenziswa ukulungiselela usawoti we-phenylalanine noma usawoti we-amino acid ohambisanayo kusuka kusawoti we-phenylpyruvic acid noma ama-derivatives.
Uhlobo lokusabela kwe-Catalytic:

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

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