Isithombe Esifakiwe se-Cyclooxygenase (COX)

I-Cyclooxygenase (COX)

Incazelo emfushane:

Mayelana ne-Cyclooxygenase

I-ES-COX (i-Cyclooxygenase): ivuselela ukuguqulwa kwezibopho ze-C=C zibe yi-epoxide. Kunezinhlobo ezingu-11 zemikhiqizo ye-enzyme ye-COX (Inombolo njenge-ES-COX101~ ES-COX-111) eyenziwe yi-SyncoZymes. Ngokwendlela ehlukene yokucubungula, i-COX ye-SyncoZymes ihlukaniswe yi-haloperoxidase kanye ne-styrene monooxygenase. I-ES-COX101, 102, 107-111 ingeye-haloperoxidase, kanti i-ES-COX103-106 ingeye-styrene monooxygenase.

Iselula/I-Wechat/I-WhatsApp: +86-13681683526

I-imeyili:lchen@syncozymes.com

Sithumelele i-imeyili

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Mayelana ne-Cyclooxygenase:

Uhlobo lokusabela kwe-Catalytic:

I-Haloperoxidase:

I-Styrene monooxygenase:

Ulwazi Lomkhiqizo:

Ama-enzyme	Ikhodi Yomkhiqizo	Imininingwane
Impuphu ye-Enzyme	I-ES-COX-101~ I-ES-COX-110	isethi ye-10 NADH Cyclooxygenase, 50 mg ngayinye Izinto eziyi-10 * 50mg / into, noma olunye ubuningi

Izinzuzo:

★ Ukucaciswa okuphezulu kwe-substrate.
★ Ukukhetha okunamandla kwe-chiral.
★ Ukuguqulwa okuphezulu.
★ Imikhiqizo embalwa engaphansi.
★ Izimo zokusabela okuncane.
★ Inobungani nemvelo.

Imiyalelo yokusebenzisa:

➢ Ngokuvamile, uhlelo lokusabela lwe-haloperoxidase luhlanganisa: i-substrate, i-buffer, i-enzyme, i-H2O2 kanye ne-halogen ion. Uhlelo lokusabela lwe-styrene monooxygenase luhlanganisa i-substrate, i-buffer, i-enzyme, i-coenzyme kanye nohlelo lokuvuselela i-coenzyme
➢ I-COX kufanele ifakwe ekugcineni ohlelweni lokusabela, ngemuva kokuthi i-pH kanye nokushisa sekulungisiwe esimweni sokusabela.

Izibonelo Zokusetshenziswa:

Isibonelo 1 (Ukwenziwa kwezinto eziphuma ku-epoxy styrene ezivela kuzinto eziphuma ku-styrene)⁽¹⁾:

Qaphela: izibonelo zokusetshenziswa kanye nezinkomba zenzelwe ukukhombisa ububanzi bokusetshenziswa kwe-COX ukuze kube lula ukuqonda, futhi azihambisani ne-enzyme ethile ye-SyncoZymes.

Isitoreji:

Gcina iminyaka emibili ngaphansi kuka -20℃.

Ukunakwa:

Ungalokothi uthinte izimo ezimbi kakhulu ezifana nalezi: izinga lokushisa eliphezulu, i-pH ephezulu/ephansi kanye nesinyibilikisi se-organic esinomthamo ophezulu.