I-Imine reductase (IRED)
Incazelo emfushane:
Mayelana ne-Imine reductase
ES-IRED: Ikilasi lama-enzyme adala ukuncipha kwesibopho se-C=N kubhondi ye-CN.Kungokwe-redox enzyme, ene-coenzyme NADPH yokuhamba nge-hydrogen.Ngokuya ngokuthandwa kwe-chiral kwemikhiqizo, ingahlukaniswa nge-R-IRED kanye ne-S-IRED.Ama-syncozymes athuthukise ama-imine reductases angu-15 (numbIRED ES-IRED-101-ES-IRED-115), angasetshenziswa kakhulu ekunciphiseni i-regioselective kanye ne-stereoselective yama-imine ukuze kulungiswe ama-chiral amines.
Uhlobo lokusabela kwe-Catalytic:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyili:lchen@syncozymes.com
| Ama-enzyme | Ikhodi Yomkhiqizo | Ukucaciswa |
| I-Enzyme Powder | ES-IRED-101~ ES-IRED-114 | isethi ye-14 Imine Reductase, 50 mg ngayinye |
| Ikhithi Yokuhlola I-Enzyme engu-96 | ES-IRED-1400 | isethi ye-14 Imine Reductase, 1 mg ngayinye |
★ Ukucaciswa okuphezulu kwe-substrate.
★ Ukukhetha okuqinile kwe-chiral.
★ ukuguqulwa okuphezulu.
★ Imikhiqizo engaphansi.
★ Izimo zokusabela ezithambile.
★ Ayinandaba nemvelo.
➢ Ngokuvamile, isistimu yokusabela kufanele ifake i-substrate, isisombululo se-buffer, i-enzyme, i-coenzyme, nesistimu yokuvuselela i-coenzyme.
➢ Zonke izinhlobo ze-ES-IRED ezihambisana nezimo zokusabela ezifanele kufanele zifundwe ngazodwana.
➢ I-substrate egxilile kakhulu noma umkhiqizo onawo ungase uvimbele umsebenzi we-ES-IRED.Kodwa-ke, ukuvimbela kungakhululwa ngokungezwa kwe-batch ye-substrate.
Isibonelo 1(I-Biosynthesis ye-chiral 2-methyl pyrrolidine)(1):
Isibonelo 2(I-Biosynthesis ye-amine yesibili)(2):
Isibonelo sesi-3 (Ukwehliswa kwe-Imines yama-Cyclic)(3):
Gcina iminyaka emi-2 ngaphansi -20 ℃.
Ungalokothi uthintane nezimo eziyingozi kakhulu ezifana nalezi: izinga lokushisa eliphezulu, i-pH ephezulu/ephansi kanye ne-solvent ephilayo egxilile.
1. Scheller PN, Fademrecht S, Hofelzer S, et al.I-ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, et al.I-ChemCatChem, 2016, 8, 2023-2026.
3. U-Li H, uLuan ZJ, u-Zheng GW, et al.Adv.I-Synth.I-Catal.2015, 357, 1692-1696.
