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I-Nucloside phosphorylse (NP)
Mayelana ne-nucleoside phosphorylse
Kunezinhlobo ezintathu zemikhiqizo ye-enzyme ye-NP (Inombolo njenge-ES-NP-101~ ES-NP-103) eyathuthukiswa yi-SyncoZymes. I-ES-NP-101 yi-purine nucleoside phosphorylase, i-ES-NP-102 kanye ne-ES-NP-103 yi-pyrimidine nucleoside phosphorylase. I-Nucleosidephosphorylase ingahlukanisa ama-nucleoside abe yizisekelo kanye ne-pentose phosphate. I-Nucleoside phosphorylase ingahlukaniswa ibe yi-purine nucleoside phosphorylase kanye ne-pyrimidine nucleoside phosphorylase ngokuya ngokuthanda kwezisekelo ze-nucleoside. I-purine nucleoside phosphorylase ingaguqula i-adenosine ibe yi-adenine, i-inosine ibe yi-hypoxanthine, i-guanosine ibe yi-guanine, futhi ikhiqize i-ribose phosphate ngesikhathi esifanayo. I-Pyrimidine nucleoside phosphorylase ingaguqula i-uridine ibe yi-uracil futhi ikhiqize i-ribose phosphate.
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I-Hydroaminase (HAM)
Mayelana ne-Hydroaminase
Kunezinhlobo ezimbili zomkhiqizo we-enzyme ye-HAM (Inombolo njenge-ES-HAM-101~ ES-HAM-102) eyathuthukiswa yi-SyncoZymes. I-HAM ingavuselela i-ammonia ye-enoic acid noma izinto eziphuma kuyo ukuze ikhiqize ama-amino acid e-chiral. I-HAM ingasetshenziswa ukuhlanganisa ama-amino acid e-chiral (noma ama-chiral amines) avela kuma-enoic acid (noma ama-alkenes). Umnikeli we-ammonia, njengamanzi e-ammonia noma usawoti we-ammonium, uyadingeka.
Uhlobo lokusabela kwe-Hydroaminase catalytic
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I-CALB Engashukumi
I-CALB
I-Recombinant Lipase B evela ku-Candida antarctica (CALB) ikhiqizwa ngokubiliswa okucwiliswe emanzini nge-Pichia pastoris eguquliwe ngokwezakhi zofuzo.
I-CALB ingasetshenziswa esigabeni samanzi noma esigabeni se-organic catalytic esterification, i-esterosis, i-transesterification, i-ring opening polyester synthesis, i-aminolysis, i-hydrolysis yama-amides, i-acylation yama-amine kanye nokusabela kokwengeza.
I-CALB inokukhetha okuphezulu kwe-chiral kanye nokukhetha kwesikhundla, ngakho-ke ingasetshenziswa kabanzi ekucubungulweni kwamafutha, ekudleni, emithini, ezimonyweni nakwezinye izimboni zamakhemikhali.
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I-NADH oxidase (NOX)
Mayelana ne-NADH oxidase
I-ES-NOX (i-NADH oxidase): I-NOX ivuselela ukushiswa kwe-NADH ibe yi-NAD+, futhi ingeye-oxidoreductase. Enkambisweni yokushiswa, i-O2 iyadingeka njenge-oxidant, futhi yehliswa ibe yi-H2O noma i-H2O2. Kunezinhlobo ezine zemikhiqizo ye-enzyme ye-NOX (ES-NOX-101~ES-NOX-104) eyenziwe yinkampani yethu, engasetshenziswa ekuvuseleleni ukushiswa kwe-coenzyme NAD+.
Uhlobo lokusabela kwe-Catalytic:
or
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I-Phenylalanine ammonia lyase (PAL)
Mayelana ne-Phenylalanine ammonia lyase
I-ES-PAL: Uhlobo lwama-enzyme avuselela ukuqedwa okuqondile kwe-L-phenylalanine kube yi-transcinnamic acid. Ama-Syncozymes athuthukise izinto eziyi-10 ze-phenylalanine ammonia lyase (ezinenombolo ye-ES-PAL-101~ES-PAL-110), ezingasetshenziswa ekuqedweni noma ekuphenduleni okuphambene kwe-phenylalanine kanye nezinto eziphuma kuyo.
Uhlobo lokusabela kwe-Catalytic:
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I-Catalase (i-CAT)
Mayelana ne-Catalase
I-ES-CAT (i-Catalase): ivuselela ukubola kwe-H2O2 ibe umoya-mpilo namanzi. Itholakala kakhulu kuma-mitochondria, endoplasmic reticulum, esibindini sezilwane kanye namangqamuzana egazi abomvu, ikakhulukazi esibindini lapho kugxilwe kakhulu, ihlinzeka ngomsebenzi wokuvikela umzimba nge-antioxidant. Ku-biocatalysis, isetshenziswa kakhulu ukususa i-hydrogen peroxide yomkhiqizo osabelayo kanye nokunciphisa ukuvinjelwa kanye nokungasebenzi kwe-enzyme yi-hydrogen peroxide. Kukhona uhlobo olulodwa kuphela lwemikhiqizo ye-enzyme ye-CAT eyenziwe yi-SyncoZymes (Inombolo njenge-ES-CAT).
Uhlobo lokusabela kwe-Catalytic:
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I-Lysine oxidase (LO)
Mayelana ne-Lysine oxidase
I-ES-LO (i-Lysine oxidase): ivuselela ukukhiqizwa kwe-L-lysine ibe yi-6-amino-2-oxohexanoic acid (noma i-lactone yayo). Kukhona uhlobo olulodwa kuphela lomkhiqizo we-enzyme ye-LO (Inombolo njenge-ES-LO) eyathuthukiswa yi-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:
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I-Phosphokinase (PKase)
Mayelana ne-Phosphokinase
I-ES-PKase (i-Phosphokinase): ivuselela ukudluliselwa kwamaqembu e-phosphate ku-ATP kwamanye ama-compounds. Iphinde ivuselele ukudluliselwa kwamaqembu e-phosphate kwamanye ama-nucleoside e-triphosphate ngezinye izikhathi. Ama-kinase amaningi adinga ama-ion ensimbi ahlukene ukuze ahlanganyele ekusabeleni (ngokuvamile i-Mg2+). Kunezinhlobo ezingu-21 zemikhiqizo ye-enzyme ye-PKase (Inombolo njenge-ES-PKase101~ ES-PKase-121) eyenziwe yi-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:
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I-Cyclooxygenase (COX)
Mayelana ne-Cyclooxygenase
I-ES-COX (i-Cyclooxygenase): ivuselela ukuguqulwa kwezibopho ze-C=C zibe yi-epoxide. Kunezinhlobo ezingu-11 zemikhiqizo ye-enzyme ye-COX (Inombolo njenge-ES-COX101~ ES-COX-111) eyenziwe yi-SyncoZymes. Ngokwendlela ehlukene yokucubungula, i-COX ye-SyncoZymes ihlukaniswe yi-haloperoxidase kanye ne-styrene monooxygenase. I-ES-COX101, 102, 107-111 ingeye-haloperoxidase, kanti i-ES-COX103-106 ingeye-styrene monooxygenase.
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I-Cyclohexanone monooxygenase (CHMO)
Mayelana ne-Cyclohexanone monooxygenase
I-ES-CHMO (i-Cyclohexanone monooxygenase): i-Baeyer Villiger monooxygenase (BVMO) ene-cyclohexanone njenge-substrate, ingaxuba i-cyclohexanone ibe yi-cyclohexanol isebenzisa i-oxygen.
Luhlobo lwe-enzyme encike ku-flavin. I-flavin e-oxidized incishiswa ibe yi-flavin ngomjikelezo wokunciphisa i-coenzyme II (NADPH) ukuze kutholakale i-oxidation elandelayo. Ngakho-ke, i-cofactor NADPH iyadingeka emjikelezweni we-flavin. Kukhona uhlobo olulodwa kuphela lomkhiqizo we-enzyme ye-CHMO (Inombolo njenge-ES-CHMO101) eyakhiwa yi-SyncoZymes, engasetshenziswa ukuxubha i-cyclohexanone ibe yi-cyclohexanone.
Uhlobo lokusabela kwe-Catalytic:
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I-Carboxylic acid reductase (CAR)
Mayelana ne-Carboxylic acid reductase
I-ES-CAR (i-Carboxylic acid reductase): ivuselela ukwehla kweqembu le-carboxyl libe yiqembu le-aldehyde. Enqubweni yokuvuselela, ukusebenza kwe-ATP kanye ne-coenzyme NADPH kuyadingeka njengabathuthi be-hydrogen. Kunezinhlobo ezimbili zemikhiqizo ye-enzyme ye-CAR (Inombolo njenge-ES-CAR101~ ES-CAR-102) eyenziwe yi-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:
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I-Phenylalanine dehydrogenase (PDH)
Mayelana ne-Phenylalanine dehydrogenase
I-ES-PDH: Uhlobo lwe-oxidoreductase. Ukusabela okuhle kungavuselela ukususwa kwe-oxidative kwe-L phenylalanine salt lapho kukhona i-NAD ukuze kukhiqizwe usawoti we-phenylpyruvate, kanti ukusabela okuphambene nakho kungavuselela ukwenziwa kwe-amino acid salt ehambisanayo kusuka kusawoti we-phenylpyruvate. Ama-Syncozymes athuthukise izinto ezingu-8 ze-phenylalanine dehydrogenase (ezinenombolo ze-ES-PDH-101~ES-PDH-108). I-ES-PDH ingasetshenziswa ukulungiselela usawoti we-phenylalanine noma usawoti we-amino acid ohambisanayo kusuka kusawoti we-phenylpyruvic acid noma ama-derivatives.
Uhlobo lokusabela kwe-Catalytic:
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I-imeyili:lchen@syncozymes.com
