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I-Nucloside phosphoryalse (NP)
Mayelana ne-nucleoside phosphoryalse
Kunezinhlobo ezi-3 zemikhiqizo ye-enzyme ye-NP (Inombolo njengokuthi ES-NP-101~ ES-NP-103) eyakhiwe yi-SyncoZymes.I-ES-NP-101 i-purine nucleoside phosphorylase, i-ES-NP-102 ne-ES-NP-103 yi-pyrimidine nucleoside phosphorylase.I-Nucleosidephosphorylase ingabola ama-nucleoside abe yizisekelo kanye ne-pentose phosphate.I-Nucleoside phosphorylase ingahlukaniswa ibe yi-purine nucleoside phosphorylase ne-pyrimidine nucleoside phosphorylase ngokuvumelana nokuthandwa kwezisekelo ze-nucleoside.I-Purine nucleoside phosphorylase ingakwazi ukugaya i-adenosine ku-adenine, inosine ku-hypoxanthine, i-guanosine ku-guanine, futhi ikhiqize i-ribose phosphate ngesikhathi esifanayo.I-Pyrimidine nucleoside phosphorylase ingakwazi ukugaya i-uridine ku-uracil futhi ikhiqize i-ribose phosphate.
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IHydroaminase (HAM)
Mayelana neHydroaminase
Kunezinhlobo ezi-2 zomkhiqizo we-enzyme ye-HAM (Inombolo njengokuthi ES-HAM-101~ ES-HAM-102) eyakhiwe yi-SyncoZymes.I-HAM ingakwazi ukuvuselela i-ammoniation ye-enoic acid noma okuphuma kuyo ukukhiqiza ama-chiral amino acid.I-HAM ingasetshenziswa ukwenza ama-chiral amino acid (noma ama-chiral amines) asuka kuma-enoic acid (noma ama-alkenes).Umnikezeli we-ammonia, njengamanzi ammonia noma usawoti we-ammonium, uyadingeka.
Uhlobo lokusabela lwe-Hydroaminase
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I-CALB engakwazi ukuhamba
I-CALB
I-Recombinant Lipase B evela ku-Candida antarctica (CALB) ikhiqizwa ngokuvutshelwa okungaphansi kwamanzi nge-Pichia pastoris eguqulwe ngofuzo.
I-CALB ingasetshenziswa esigabeni samanzi noma isigaba se-organic catalytic esterification, i-esterolysis, i-transesterification, i-polyester yokuvula indandatho, i-aminolysis, i-hydrolysis yama-amides, i-acylation yama-amine kanye nokusabela kokwengeza.
I-CALB inokukhetha okuphezulu kwe-chiral kanye nokukhetha isikhundla, ngakho-ke ingasetshenziswa kabanzi ekucubunguleni uwoyela, ukudla, imithi, izimonyo nezinye izimboni zamakhemikhali.
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I-NADH oxidase (NOX)
Mayelana ne-NADH oxidase
I-ES-NOX (i-NADH oxidase): I-NOX yenza i-oxidation ye-NADH iye ku-NAD+, futhi ingeye-oxidoreductase.Enqubweni ye-oxidation, i-O2 iyadingeka njenge-oxidant, futhi yehliselwe ku-H2O noma i-H2O2.Kunezinhlobo ezi-4 zemikhiqizo ye-enzyme ye-NOX (ES-NOX-101~ES-NOX-104) eyenziwe yinkampani yethu, engasetshenziselwa ukuvuselelwa kwe-oxidation ye-coenzyme NAD +.
Uhlobo lokusabela kwe-Catalytic:
or
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I-imeyili:lchen@syncozymes.com
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I-Phenylalanine ammonia lyase (PAL)
Mayelana ne-Phenylalanine ammonia lyase
I-ES-PAL: Isigaba sama-enzyme enza ukuthi i-L-phenylalanine ibe yi-transcinnamic acid.Ama-syncozymes akhiqize izinto eziyi-10 ze-phenylalanine ammonia lyase (ezinezinombolo ezingu-ES-PAL-101~ES-PAL-110), ezingasetshenziswa e-deamination noma ekuphenduleni okuhlanekezelwe kwe-phenylalanine kanye nokuphuma kwayo.
Uhlobo lokusabela kwe-Catalytic:
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Isi-Catalase (CAT)
Mayelana neCatalase
I-ES-CAT (Catalase): ikhuthaza ukubola kwe-H2O2 ibe umoya-mpilo namanzi.Itholakala ikakhulukazi ku-mitochondria, i-endoplasmic reticulum, isibindi sesilwane namangqamuzana egazi abomvu, ikakhulukazi esibindini ekugxilweni okuphezulu, okuhlinzeka ngokusebenza kokuzivikela kwe-antioxidant emzimbeni.Ku-biocatalysis, isetshenziswa ikakhulukazi ukususa ukusabela ngomkhiqizo we-hydrogen peroxide futhi kuncishiswe ukuvinjwa kanye nokungasebenzeki kwe-enzyme nge-hydrogen peroxide.Kunohlobo olungu-1 kuphela lwemikhiqizo ye-enzyme ye-CAT eyakhiwe yi-SyncoZymes (Inombolo njenge-ES-CAT).
Uhlobo lokusabela kwe-Catalytic:
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I-Lysine oxidase (LO)
Mayelana ne-Lysine oxidase
I-ES-LO (i-Lysine oxidase): yenza i-oxidation ye-L-lysine iye ku-6-amino-2-oxohexanoic acid (noma i-lactone yayo).Kunohlobo olungu-1 kuphela lomkhiqizo we-enzyme ye-LO (Inombolo njengokuthi ES-LO) eyakhiwe i-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:
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I-Phosphokinase (PKase)
Mayelana nePhosphokinase
I-ES-PKase (i-Phosphokinase): igqugquzela ukudluliselwa kwamaqembu e-phosphate ku-ATP kwezinye izinhlanganisela.Iphinde ikhuthaze ukudluliswa kwamaqembu e-phosphate kwamanye ama-nucleoside e-triphosphate ngezinye izikhathi.Ama-kinase amaningi adinga ama-ion ensimbi e-divalent ukuze abambe iqhaza ekuphenduleni (ngokuvamile i-Mg2+).Kunezinhlobo ezingu-21 zemikhiqizo ye-enzyme ye-PSase (Inombolo njenge-ES-PKase101~ ES-PKase-121) eyakhiwe yi-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:
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I-Cyclooxygenase (COX)
Mayelana ne-Cyclooxygenase
I-ES-COX (i-Cyclooxygenase): igqugquzela ukuguqulwa kwamabhondi e-C=C abe yi-epoxide.Kunezinhlobo ezingu-11 zemikhiqizo ye-enzyme ye-COX (Inombolo njenge-ES-COX101~ ES-COX-111) eyakhiwe yi-SyncoZymes.Ngokuya ngendlela ehlukile ye-catalytic, i-COX ye-SyncoZymes ihlukaniswe yaba i-haloperoxidase ne-styrene monooxygenase.I-ES-COX101, 102, 107-111 ingeye-haloperoxidase, kuyilapho i-ES-COX103-106 ingeye-styrene monooxygenase.
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I-Cyclohexanone monooxygenase (CHMO)
Mayelana ne-Cyclohexanone monooxygenase
I-ES-CHMO (Cyclohexanone monooxygenase): i-Baeyer Villiger monooxygenase (BVMO) ene-cyclohexanone njenge-substrate, inga-oxidize i-cyclohexanone ku-cyclohexanol isebenzisa umoya-mpilo.
Iwuhlobo lwe-enzyme encike ku-flavin.I-flavin ene-oxidized iyancipha ibe yi-flavin ngomjikelezo wokunciphisa i-coenzyme II (NADPH) ye-oxidation elandelayo.Ngakho-ke, i-cofactor NADPH iyadingeka kumjikelezo we-flavin.Kunohlobo olungu-1 kuphela lomkhiqizo we-enzyme ye-CHMO (Inombolo njengokuthi ES-CHMO101) ethuthukiswe yi-SyncoZymes, engasetshenziswa ukwenza i-cyclohexanone ibe yi-cyclohexanone.
Uhlobo lokusabela kwe-Catalytic:
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I-Carboxylic acid reductase (CAR)
Mayelana ne-Carboxylic acid reductase
I-ES-CAR (i-Carboxylic acid reductase): ikhuthaza ukuncipha kweqembu le-carboxyl eqenjini le-aldehyde.Enqubweni ye-catalytic, ukuqaliswa kwe-ATP kanye ne-coenzyme NADPH kuyadingeka njengezithuthi ze-hydrogen.Kunezinhlobo ezi-2 zemikhiqizo ye-enzyme ye-CAR (Inombolo njenge-ES-CAR101~ ES-CAR-102) eyakhiwe yi-SyncoZymes.
Uhlobo lokusabela kwe-Catalytic:
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I-Transaldolase (TAL)
Mayelana neTransaldolase
I-ES-TAL (Transaldolase): ikakhulukazi ibhekisela ku-threonine transaldolases, engase ibangele ukusabela ukuze kuhlanganiswe okuphuma kokuphuma kwe-β-hydroxyphenylalanine nge-threonine kanye nokuphuma kwe-benzaldehyde.I-TAL iyi-enzyme encike ku-PLP.Kunohlobo olungu-1 kuphela lomkhiqizo we-enzyme ye-TAL (Inombolo njengokuthi ES-TAL101) ethuthukiswe i-SyncoZymes, engasetshenziswa ukuze kuhlanganiswe i-β-hydroxyphenylalanine kanye nokuphuma kwayo.
Uhlobo lokusabela kwe-Catalytic:
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I-imeyili:lchen@syncozymes.com
