I-β-Nicotinamide Mononucleotide (NMN)
Muva nje, kunezindaba ezinhle emkhakheni we-NMN - ngemva kokubuyekezwa okuqinile kwekomiti lochwepheshe lenhlangano egunyaziwe ye-US Food and Drug Administration (FDA), izinto zokusetshenziswa ze-NMN ze-Shangke Biopharmaceutical (Shanghai) Co., Ltd. (ngemuva kwalokhu okuzoshiwo khona kamuva) ukuze "njenge-Shangke Bio") kuvunywe imvume ye-United States ye-FDA NDI iqinisekisa ukuthi impahla yayo eluhlaza ye-NMN ingasetshenziswa ngokusemthethweni ekukhiqizeni, ekuthengisweni nasekukhuthazeni izithasiselo zokudla e-United States, futhi ingatholakala kwisikhulu se-FDA. iwebhusayithi njengesengezo esisha sokudla okuluhlaza, inombolo 1247.
I-FDA NDI iwuhlelo lwesitifiketi olubaluleke kakhulu emakethe yase-US.Ukuthola lesi sitifiketi akusho nje kuphela ukuthi ukuphepha nekhwalithi yemikhiqizo ye-Shangke Bio injaloyaziwa kakhulu, kodwa futhi isiza ekuthuthukisweni okujwayelekile okuqhubekayo kwemboni ye-NMN ngokuhamba kwesikhathi.
| Igama Lekhemikhali | I-β-Nicotinamide Mononucleotide |
| Omqondofana | I-NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE |
| Inombolo ye-CAS | 1094-61-7 |
| Isisindo samangqamuzana | 334.22 |
| I-Molecular Formula | I-C11H15N2O8P |
| I-EINECS: | 214-136-5 |
| Iphoyinti lokuncibilika | 166 °C(dec.) |
| izinga lokushisa lokugcina. | -20°C |
| ukuncibilika | I-DMSO (Kancane, Yashisisa), I-Methanol (Kancane), Amanzi (Kancane) |
| ifomu | Okuqinile |
| umbala | Okumhlophe kuya Kuphuzi |
| I-Merck | 13,6697 |
| I-BRN | 3570187 |
| Ukuzinza: | I-Hygroscopic kakhulu |
| I-InChIKey | I-DAYLJWODMCOQEW-TURQNECASA-N |
| Into yokuhlola | Imininingwane |
| Ukubukeka | Impushana yekristalu emhlophe ukuya kokumhlophe |
| Okuqukethwe kwe-sodium | ≤1% |
| Inani le-pH (100mg/ml) | 2.0~4.0 |
| Ubumsulwa | ≥99.0% |
| Okuqukethwe kwamanzi | ≤1% |
| Izinsimbi ezinzima | <10ppm |
| I-Arsenic | <0.5ppm |
| Ukuhola | <0.5ppm |
| I-Mercury | <0.1ppm |
| I-Cadmium | <0.5ppm |
| Izinsalela ze-solvent | I-Ethanol≤1000ppm |
| Isamba se-Aerobic Microbial Count | <750cfu/g |
| Imvubelo & Isikhunta | <25cfu/g |
| I-coliform ephelele | ≤0.92MPN/g |
| E. Coli | Okubi |
| I-Salmonella | Okubi |
| Staph.I-Aureus | Okubi |
| I-Assay (ngokwesisekelo se-anhydrous) | ≥99.0% |
| Izinga lokuhlunga | ≥95% |
| Ukuminyana ngobuningi | Bika ukuze uthole ulwazi |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Londoloza ezitsheni eziqinile, ezimelana nokukhanya, ukuze ugcine isikhathi eside ugcine ku-2~8°C noma ngaphansi.
I-Nicotinamide Mononucleotide (NMN) iwuhlobo olusha lwevithamini B3 eyisinyathelo esingu-1 esandulela i-NAD+ (Nicotinamide Adenine Dinucleotide).I-NMN iyisibuyisi sokuqala se-NAD+ esifakazelwe sisebenza ngempumelelo ukubuyisela amaseli ku-vivo.
INicotinamide Adenine Dinucleotide (NAD) ingenye yama-molecule abaluleke kakhulu futhi athakazelisa emzimbeni.Iyadingeka ekuphenduleni kwe-enzymatic okungaphezulu kwe-500 futhi idlala indima ebalulekile ekulawuleni cishe zonke izinqubo ezinkulu zebhayoloji (Ansari noRaghava, 2010).Ngaphezu kwakho konke, kungase kusivumele ukuba siphile ukuphila okunempilo nokude.
I-Nicotinamide Adenine Dinucleotide (NAD) ikhona noma ngabe ifomu layo eline-oxidized (NAD+) noma ifomu elincishisiwe (NADH), okungamacofactor abalulekile enombolo ye-oxireductase.
I-SyncoZyems njengowokuqala ukuthola i-FDA NDI NMN egunyazwe ibhizinisi lokukhiqiza impahla eluhlaza, imele isikhulu se-FDA samukela i-NMN njengohlobo olusha lwempahla engaqala ukwamukelwa nokugunyazwa ngezithako zesengezo sokudla e-United States.
