I-β-Nicotinamide adenine dinucleotide (i-asidi yamahhala) (NAD)
I-NAD iyi-coenzyme evame kakhulu ye-dehydrogenase ezintweni eziphilayo.Ibamba iqhaza ekuphenduleni kwe-redox ezintweni eziphilayo, futhi ithutha futhi idlulise ama-electron ezinto ekuphenduleni.I-Dehydrogenase idlala indima ebalulekile kumetabolism yomuntu.Okunye ukunyakaza okuyisisekelo kwe-metabolic emzimbeni womuntu, njengokubola kwamaprotheni, ukubola kwe-carbohydrate, nokubola kwamafutha, akukwazi ukwenziwa ngokujwayelekile ngaphandle kwe-dehydrogenase, futhi abantu bazolahlekelwa izimpawu ezibalulekile.Futhi ngenxa yokuthi inhlanganisela ye-NAD ne-dehydrogenase ingakhuthaza umzimba, ngakho-ke i-NAD iyingxenye ebalulekile yomzimba womuntu.Ngokusho kokusetshenziswa komkhiqizo, ingahlukaniswa ngamamaki alandelayo: ibanga le-biotransformation, ibanga le-diagnostic reagent, ibanga lokudla kwezempilo, i-API kanye nezinto zokusetshenziswa zokulungiselela.
| Igama Lekhemikhali | I-Nicotinamide adenine dinucleotide (i-asidi yamahhala) |
| Omqondofana | I-β-Nicotinamide adenine dinucleotide |
| Inombolo ye-CAS | 53-84-9 |
| Isisindo samangqamuzana | 663.43 |
| I-Molecular Formula | I-C21H27N7O14P2 |
| I-EINECS: | 200-184-4 |
| Iphoyinti lokuncibilika | 140-142 °C (wohloka) |
| izinga lokushisa lokugcina. | -20°C |
| ukuncibilika | I-H2O: 50 mg/mL |
| ifomu | Impushana |
| umbala | Emhlophe |
| I-Merck | 14,6344 |
| I-BRN | 3584133 |
| Ukuzinza: | Izinzile.I-Hygroscopic.Akuhambisani nama-oxidizing agents aqinile. |
| I-InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Into yokuhlola | Imininingwane |
| Ukubukeka | Impushana yekristalu emhlophe ukuya kokumhlophe |
| Ukuhlaziywa kwe-spectral ye-UV εku-260 nm kanye ne-pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Ukuncibilika | 25mg/mL 25mg/mL emanzini |
| Okuqukethwe (ngokuhlaziywa kwe-enzymatic nge-ADH ku-pH 10, kusetshenziswa i-spectrophotometer, i-abs.340nm, kusisekelo se-anhydrous) | ≥98.0% |
| I-Assay (nge-HPLC, ngesisekelo se-anhydrous) | 98.0~102.0% |
| Ukuhlanzeka (nge-HPLC, %indawo) | ≥99.0% |
| Okuqukethwe kwamanzi (nge-KF) | ≤3% |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina umiswe ngokuqinile ebumnyameni, ukuze isitoreji eside sigcine ku-2~8℃.
Ibanga le-Biotransformation: Ingasetshenziselwa ukuhlanganiswa kwe-biocatalytic ye-intermediate yemithi kanye nama-API, ikakhulukazi ngama-enzyme e-catalytic, njenge-ketoreductase (KRED), i-nitroreductase (NTR), i-P450 monooxygenase (CYP), i-formate dehydrogenase (FDH)), i-glucose dehydrogenase ( GDH), njll., ezingabambisana ukuguqula iziphakathi ze-amino acid nezinye izidakamizwa ezihlobene.Njengamanje, izimboni eziningi zemithi yasekhaya seziqalile ukufaka esikhundleni se-enzyme yebhayoloji, futhi isidingo semakethe ye-NAD+ sikhula ngokushesha.
Ibanga le-Diagnostic reagent: Ihlanganiswe nezinhlobonhlobo zama-enzymes okuxilonga, njengempahla eluhlaza yamakhithi okuxilonga.
Ibanga lokudla kwezempilo: I-NAD iyi-coenzyme ye-dehydrogenase.Idlala indima engenakuthathelwa indawo ku-glycolysis, gluconeogenesis, umjikelezo we-tricarboxylic acid, kanye neketango lokuphefumula, idlala indima ebalulekile ekukhiqizweni kwamandla, futhi isiza ekukhiqizeni i-L-dopa, eba yi-dopamine Neurotransmitters.Ikakhulukazi eminyakeni yamuva, kuye kwatholakala ukuthi "injini" kanye "nophethiloli" ohlelweni lokulungisa umonakalo wamangqamuzana.Ngokusho kocwaningo, ukwengezwa kwama-coenzymes (kuhlanganise ne-NMN, NR, NAD, NADH) ku-vitro kungathuthukisa umthamo we-antioxidant wamangqamuzana ezicubu, kuvimbele ukusayina kwe-apoptosis, ukubuyisela ukusebenza kwamaseli okuvamile, ukuvimbela ukuvela kwezifo noma ukuvimbela ukuqhubeka kwesifo.
Ukwengeza, ama-coenzymes angakwazi ukuthuthukisa ikhono lokuphendula kwamasosha omzimba ngokusebenza nokugqugquzela ukuvuthwa kwamangqamuzana omzimba okuzalwa, ukukhiqiza izici eziphikisana nokuvuvukala kanye nokucindezela amaseli e-T alawulayo. I-Nicotinamide dinucleotide oxidation state (NAD +) iyi-coenzyme etholakala kuwo wonke amaseli aphilayo.Idlala indima ebalulekile emakhulwini ezinqubo ze-metabolic emangqamuzaneni, ibamba iqhaza ezinkulungwaneni zokusabela komzimba, futhi iyilungu elibaluleke kakhulu lochungechunge lwezokuthutha lwama-electron.Umnikezeli we-hydrogen;ngesikhathi esifanayo, i-coenzyme I isebenza njengengxenye eyodwa kuphela yama-enzyme ahlobene emzimbeni, esiza ukugcina umsebenzi wama-enzyme.
I-Nicotinamide mononucleotide (NMN) iyinhlanganisela eyandulela ye-nicotinamide adenine dinucleotide oxidation state (NAD+), ebandakanyeka ekuhlanganisweni kwe-NAD ku-vivo.Ngo-2013, uProfesa David Sinclair we-Harvard Medical School wathola ukuthi ngokukhula, izinga le-cofactor coenzyme I (NAD+) ye-protein yokuphila isikhathi eside emzimbeni liyaqhubeka nokwehla, okuholela ekwehleni komsebenzi we-mitochondrial we-"dynamo" yeseli, okubangela ukuguga. , kanye nezici ezihlukahlukene emzimbeni.Ukungasebenzi kahle kwalolu hlobo lomsebenzi kukhiqizwa kanjalo.Ngokusho kochungechunge lwezifundo zakhe, okuqukethwe kwe-NAD + emzimbeni womuntu kuncipha ngokuya ngeminyaka, okuholela ekugugeni ngokushesha kusuka eminyakeni engama-30, nemibimbi, ukuphumula kwemisipha, ukunqwabelana kwamafutha, kanye nezifo ezinjengesifo senhliziyo, umfutho wegazi ophakeme, unhlangothi. , isifo sikashukela kanye nesifo i-Alzheimer's anda ingozi.Isihluthulelo sokuphila isikhathi eside ukukhulisa izinga le-coenzyme I (NAD+) emzimbeni, kwandiswe izinga lokugayeka kokudla kwamangqamuzana, futhi kushukumise ubungqabavu bobusha obungaba khona.
I-API kanye nezinto zokusetshenziswa zokusetshenziswa: I-NAD+ isetshenziselwa imijovo yokwelashwa/ukulawulwa kokulutheka izidakamizwa, okuhlanganisa nokwelashwa nge-intravenous NAD IV okwenziwa e-United States, Europe, Russia, South Africa, Mexico, South America, Southeast Asia nakwamanye amazwe.Imikhiqizo ezilungiselele ekhemisi, efana namakhemisi aseMelika, ingathenga izinto ezingavuthiwe ukuze izikhiphe ngokwazo, njengamalungiselelo asesibhedlela saseShayina, ilawula ikhwalithi yezinto zokusetshenziswa ngokwayo, futhi ilungiselela amalungiselelo emithini.
