Njengoba sikhula, amathambo ethu aba ntekenteke futhi athambekele ekuqhekekeni, futhi ukwelapha kwamanje kungakhuphula ngokunesizotha ukuminyana kwamathambo.Le nkinga iphakama kakhulu ngenxa yokuthi imbangela eyinhloko ye-osteoporosis (ukuncipha kwamathambo nokuqina) akwaziwa.
Muva nje, abacwaningi base-Australia bashicilele imiphumela yocwaningo lwesayensi ku-Journal of Gerontology: Uchungechunge A: I-NMN inganciphisa ukuguga kwamangqamuzana amathambo omuntu futhi ikhuthaze ukuphulukiswa kwamathambo kumagundane we-osteoporotic."Okutholakele kubonisa i-NMN njengekhandidethi eliphumelelayo nelingenzeka lokwelapha ukuvimbela i-osteoporosis nokuthuthukisa ukuphulukiswa kwamathambo kubantu abadala asebekhulile abane-osteoporosis," kusho abalobi.
一,NMNikhuthaza ukuvuselelwa kwama-osteoblasts futhi ikhulise usayizi wamathambo
Njengezinye izitho zomzimba womuntu, amathambo enziwe ngamangqamuzana aphilayo.Ngakho-ke, amathambo amadala nawonakele ahlala eshintshwa amasha.Kodwa-ke, njengoba sikhula, ayancipha ama-osteoblasts atholakalayo, ngokwengxenye ngenxa yokuthi ama-osteoblasts avamile aba amaseli e-senescent.Amangqamuzana e-Senescent, angase aqhubekisele inqubo yokuguga, awakwazi ukwakha ithambo elisha, okuholela ekwakhiweni kwe-osteoporosis..
Abacwaningi base-Australia bafunde imiphumela ye-NMN ku-osteoporosis ngokutadisha ama-osteoblasts abantu.Ukuze kutholwe i-senescence, abacwaningi badalule ama-osteoblasts kusici esibangela ukuvuvukala esibizwa nge-TNF-⍺.Nakuba i-TNF-⍺ isheshisa ukuguga, ukwelashwa nge-NMN kunciphisa ukuguga cishe izikhathi ezingu-3, futhi imiphumela ibonise ukuthi i-NMN inciphise ama-osteoblasts abomvu.
Ama-osteoblasts anempilo akha izicubu zamathambo amasha ngokuguqula abe amaseli amathambo avuthiwe.Abacwaningi bathola ukuthi ukwenza i-senescence nge-TNF-⍺ kunciphisa ukuchichima kwamaseli amathambo avuthiwe.Kodwa-ke, i-NMN yandise ukuchichima kwamaseli amathambo avuthiwe, futhi imiphumela ibonisa ukuthi i-NMN ingakhuthaza ukwakheka kwamathambo.
Ngemva kokuthola ukuthi lokhoNMNkunganciphisa ama-osteoblasts athambile futhi kukhuthaze ukuhlukaniswa kwawo kumaseli amathambo avuthiwe, abacwaningi bahlola ukuthi lokhu kungenzeka yini ezintweni eziphilayo.Ukuze benze lokhu, bakhipha ama-ovari amagundane abesifazane futhi baphula izinsikazi zabo, okwaholela ekulahlekelweni kwamathambo okuwuphawu lwe-osteoporosis.
Ukuhlola umphumela we-NMN ku-osteoporosis, abacwaningi bajova amagundane e-osteoporotic nge-400 mg / kg / ngosuku lwe-NMN izinyanga ezingu-2.Kwatholakala ukuthi amagundane ane-osteoporosis andise ithambo, okubonisa ukuthi i-NMN iguqule kancane izimpawu ze-osteoporosis.Kuhlanganiswe nedatha ye-osteoblast yabantu, lokhu kusho ukuthi i-NMN ingase ikwazi ukwelapha i-osteoporosis ngokwandisa ukwakheka kwamathambo.
二、 Imiphumela yokuthuthukisa amathambo ye-NMN
Imiphumela yocwaningo ikhomba lokhoNMNingakhuthaza ukwakheka kwamathambo.Kubonakala ukwenza lokhu ngezindlela eziningi, okuhlanganisa ukuvuselela ama-stem cells, okubalulekile ekwakhekeni kwamathambo kanye ne-NAD+, okubalulekile ekwakhekeni kwamathambo.Amaseli we-Bone stem ahlukanisa abe ama-osteoblasts, futhi abacwaningi baye babonisa ukuthi i-NMN ingaphinde ivuselele ama-osteoblasts..
Lokhu okutholakele kusikisela ukuthi i-NMN ingase ikhulise ukwakheka kwamathambo ngokukhuthaza impilo yamangqamuzana amathambo amaningi endleleni yokwakheka kwamathambo.Nakuba kungekho miphumela yocwaningo ebonisa ukuthi i-NMN ingakhuthaza ukwakheka kwamathambo kubantu abane-osteoporosis, kungenzeka ukuthi i-NMN ingavimbela ukuthuthukiswa kwethambo okwenzeka ngokukhula.
Isikhathi sokuthumela: Jan-18-2024