Njengoba sikhula, amathambo ethu aba buthakathaka futhi athambekele ekuqhekekeni, futhi ukwelashwa kwamanje kungandisa kancane ukuqina kwamathambo. Le nkinga ivela kakhulu ngoba imbangela eyisisekelo ye-osteoporosis (ukwehla kwesisindo samathambo kanye nokuqina kwawo) ayaziwa.
Muva nje, abacwaningi base-Australia bashicilele imiphumela yocwaningo lwesayensi ku-Journal of Gerontology: Series A: NMN inganciphisa ukuguga kwamangqamuzana ethambo lomuntu futhi ikhuthaze ukuphulukiswa kwamathambo emagundwini e-osteoporotic. "Okutholakele kubonisa ukuthi i-NMN iyindlela yokwelapha ephumelelayo nengenzeka yokuvimbela i-osteoporosis nokuthuthukisa ukuphulukiswa kwamathambo kubantu abadala abane-osteoporosis," kusho abalobi.
一,I-NMNkukhuthaza ukuvuselelwa kwama-osteoblast futhi kwandisa usayizi wamathambo
Njengezinye izitho zomzimba womuntu, amathambo enziwe ngamaseli aphilayo. Ngakho-ke, amathambo amadala nawonakele athathelwa indawo amasha njalo. Kodwa-ke, njengoba siguga, kutholakala ama-osteoblast ambalwa, ngokwengxenye ngoba ama-osteoblast avamile aba amaseli avuthiwe. Amaseli avuthiwe, avame ukuqhuba inqubo yokuguga, awakwazi ukwakha amathambo amasha, okuholela ekuwohlokeni kwamathambo.
Abacwaningi base-Australia bafunde imiphumela ye-NMN ku-osteoporosis ngokutadisha ama-osteoblast abantu. Ukuze babangele ukuguga, abacwaningi baveze ama-osteoblasts ku-pro-inflammatory factor ebizwa ngokuthi i-TNF-⍺. Nakuba i-TNF-⍺ isheshisa ukuguga, ukwelashwa nge-NMN kunciphisa ukuguga cishe izikhathi ezintathu, futhi imiphumela ibonise ukuthi i-NMN inciphise ama-osteoblast asebekhulile.
Ama-osteoblast anempilo akha izicubu ezintsha zamathambo ngokuguqula zibe amangqamuzana amathambo avuthiwe. Abacwaningi bathole ukuthi ukukhuphula ukukhula nge-TNF-⍺ kunciphisa ubuningi bamangqamuzana amathambo avuthiwe. Kodwa-ke, i-NMN yandisa ubuningi bamangqamuzana amathambo avuthiwe, futhi imiphumela iphakamisa ukuthi i-NMN ingakhuthaza ukwakheka kwamathambo.
Ngemva kokutholakele ukuthiI-NMNAbacwaningi bahlole ukuthi lokhu kungenzeka yini ezintweni eziphilayo. Ukuze benze lokhu, basuse ama-ovari amagundane esifazane futhi baphula ama-femur awo, okwaholela ekulahlekelweni kwesisindo samathambo esiphawuleka nge-osteoporosis.
Ukuze bahlole umphumela we-NMN ekuwohlokeni kwamathambo, abacwaningi bajove amagundane e-osteoporotic nge-400 mg/kg/ngosuku lwe-NMN izinyanga ezimbili. Kutholakale ukuthi amagundane ane-osteoporosis ayekhuphule isisindo samathambo, okubonisa ukuthi i-NMN iguqule kancane izimpawu ze-osteoporosis. Uma ihlanganiswe nedatha ye-osteoblast yomuntu, lokhu kusho ukuthi i-NMN ingase ikwazi ukwelapha i-osteoporosis ngokwandisa ukwakheka kwamathambo.
二、 Imiphumela yokuthuthukisa amathambo ye-NMN
Imiphumela yocwaningo ikhombisa ukuthiI-NMNingakhuthaza ukwakheka kwamathambo. Kubonakala sengathi yenza lokhu ngezindlela eziningi, okuhlanganisa ukuvuselela amaseli e-bone stem, abalulekile ekwakhekeni kwamathambo kanye ne-NAD+, ebalulekile ekwakhekeni kwamathambo. Amaseli e-bone stem ahluka ngama-osteoblast, futhi abacwaningi bakhombisile ukuthi i-NMN ingavuselela nama-osteoblast.
Lokhu okutholakele kusikisela ukuthi i-NMN ingandisa ukwakheka kwamathambo ngokuthuthukisa impilo yamaseli amaningi amathambo endleleni yokwakheka kwamathambo. Nakuba kungekho miphumela yocwaningo ekhombisa ukuthi i-NMN ingakhuthaza ukwakheka kwamathambo kubantu abane-osteoporosis, kungenzeka ukuthi i-NMN ingavimbela ukukhula kwamathambo okwenzeka ngokuguga.
Isikhathi sokuthunyelwe: Jan-18-2024