I-Hypopigmentation yisifo sesikhumba, esibonakala kakhulu ngokuncipha kwe-melanin. Izimpawu ezivamile zifaka phakathi i-vitiligo, i-albinism kanye ne-hypopigmentation ngemva kokuvuvukala kwesikhumba. Njengamanje, ukwelashwa okuyinhloko kwe-hypopigmentation umuthi womlomo, kodwa umuthi womlomo uzobangela ukuwohloka kwesikhumba, ukungakhululeki kwesisu kanye neminye imiphumela emibi. Ngakho-ke, kuyadingeka ukuthuthukisa into yemvelo engenamiphumela emibi yokwelapha i-hypopigmentation.
Muva nje, i-Scientific Reports ishicilele isihloko esithi "Ukuhlola okuhlelekile kwembula amandla e-spermidine ekwelapheni i-hypopigmentation |ngokuqinisa amaprotheni ahlobene ne-melanogenesis". Imiphumela ikhombisa ukuthi i-spermidine ingelashwa ngokuzinzisa amaprotheni ahlobene ne-melanogenesis.
Ukwelashwa nge-Spermidine kwandisa ukukhiqizwa kwe-melanin
Ukuze kufundwe umphumela we-spermidine ekukhiqizweni kwe-melanin, ithimba locwaningo lelaphe i-melanin kumaseli e-MNT-1 ngamanani ahlukene e-spermidine. Ngokuhlaziywa kwenani, kwatholakala ukuthi ukwelashwa kwe-spermidine kwandisa ukukhiqizwa kwe-melanin.
I-Spermidine ingalawula uhlelo lokuwohloka kwamaprotheni oluhlobene ne-melanogenesis
Ukuze kuqinisekiswe ukuthi i-spermidine ingalawula izakhi zofuzo ezihilelekile ekuwohlokeni kwamaprotheni, ithimba locwaningo lithole izakhi zofuzo ezingu-181 zilawulwa phansi kanye nezakhi zofuzo ezingu-82 zilawulwa ngokuhlonza amaseli aphathwe i-spermidine ngendlela ehlelekile, ngaphandle kwezakhi zofuzo ezihlobene ne-melanogenesis. Ukuze kuqinisekiswe ngokwengeziwe, ithimba locwaningo lihlaziye umphumela we-spermidine ezingeni lokubonakaliswa komndeni wezakhi zofuzo ze-tyrosinase i-TYR, i-TRP-1 kanye ne-TRP-2, okuyizakhi zofuzo ezilawula kakhulu ukukhiqizwa kwe-melanin. Izinga lokubonakaliswa kwe-mRNA liqinisekisile ukuthi i-spermidine ayizange ishintshe ukubonakaliswa kwezakhi zofuzo ezihlobene ne-melanogenesis. Kodwa-ke, umsebenzi wezakhi zofuzo eziningana ushintshwa yi-spermidine futhi uhlobene nokuwohloka kwamaprotheni. Izakhi zofuzo eziningana ezishintshiwe zihlobene nobuningi, okuwuhlelo lokuwohloka kwamaprotheni oluhlobene ne-melanogenesis.
I-Spermidine ilawula ukuzinza kwamaprotheni futhi ikhuthaza ukukhiqizwa kwe-melanin.
Ukukhiqizwa kwe-melanin kulawulwa yibhalansi yokwenziwa kanye nokuwohloka kwamaprotheni ahlobene ne-melanin. I-Spermidine yelapha izakhi zofuzo ze-TYR, TRP-1 kanye ne-TRP-2. Ngokusebenza kwezakhi zofuzo zokuthutha i-SLC3A2, SLC7A1, SLC18B1 kanye ne-SLC22A18, ingakhuphula izinga lama-polyamine kumaseli, ngaleyo ndlela ikhulise ukuzinza kwamaprotheni ahlobene nokukhiqizwa kwe-melanin ukuze kukhuthazwe ukukhiqizwa kwe-melanin emzimbeni.
Ekuphetheni, lolu cwaningo lubonisa ukuthi i-spermidine ehlanganisiwe yemvelo inendima engaba khona ekwelapheni i-hypopigmentation, futhi inenani elithile lokusetshenziswa emkhakheni wezimonyo nemikhiqizo yezempilo esikhathini esizayo.
Ireferensi:
[1].Brito, S., Heo, H., Cha, B. nabanye. Ukuhlola okuhlelekile kwembula amandla e-spermidine ekwelapheni i-hypopigmentation ngokuzinzisa amaprotheni ahlobene ne-melanogenesis.Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Isikhathi sokuthunyelwe: Septhemba-28-2022