I-Hypopigmentation yisifo sesikhumba, esibonakaliswa ngokuyinhloko ngokunciphisa i-melanin.Izimpawu ezijwayelekile zihlanganisa i-vitiligo, i-albinism kanye ne-hypopigmentation ngemva kokuvuvukala kwesikhumba.Njengamanje, ukwelashwa okuyinhloko kwe-hypopigmentation imithi yomlomo, kodwa imithi yomlomo izobangela i-atrophy yesikhumba, ukungakhululeki kwamathumbu kanye neminye imiphumela emibi.Ngakho-ke, kuyadingeka ukuthuthukisa into yemvelo ngaphandle kwemiphumela emibi ukwelapha i-hypopigmentation.
Muva nje, i-Scientific Reports ishicilele isihloko esithi "Ukuhlola okuhlelekile kuveza amandla e-spermidine ekwelapheni kwe-hypopigmentation |ngokusebenzisa ukuzinza kwamaprotheni ahlobene ne-melanogenesis".Imiphumela ibonisa ukuthi i-spermidine ingelashwa ngokuzinzisa amaprotheni ahlobene ne-melanogenesis.hypopigmentation.
一、Ukwelashwa kwe-Spermidine kwandisa ukukhiqizwa kwe-melanin
Ukuze kufundwe umphumela we-spermidine ekukhiqizeni i-melanin, ithimba labacwaningi liphathe i-melanin kumaseli e-MNT-1 ngokugxilisa okuhlukene kwe-spermidine.Ngokuhlaziywa komthamo, kwatholakala ukuthi ukwelashwa kwe-spermidine kwandisa ukukhiqizwa kwe-melanin.
I-Spermidine ingalawula uhlelo lokuwohloka kwamaprotheni oluhlobene ne-melanogenesis
Ukuze kufakazele ukuthi i-spermidine ingakwazi ukulawula izakhi zofuzo ezihilelekile ekuwohlokeni kwamaprotheni, ithimba labacwaningi lithole izakhi zofuzo ezingu-181 zilawulwa phansi kanye nezakhi zofuzo ezingu-82 zilawulwa ngokuthola ngokuhlelekile amangqamuzana aphethwe yi-spermidine, ngaphandle kwezakhi zofuzo ezihlobene ne-melanogenesis.Ukufakazela ngokwengeziwe, ithimba labacwaningi lihlaziye umphumela we-spermidine ezingeni lenkulumo yomndeni we-tyrosinase TYR, TRP-1 kanye ne-TRP-2, okuyizakhi zofuzo ezilawula eduze ukukhiqizwa kwe-melanin.Izinga lesisho se-mRNA liqinisekisile ukuthi i-spermidine ayizange iguqule ukubonakaliswa kwezakhi zofuzo ezihlobene ne-melanogenesis.Kodwa-ke, umsebenzi wezakhi zofuzo eziningana ushintshwa yi-spermidine futhi uhlobene nokuwohloka kwamaprotheni.Izakhi zofuzo eziningana ezishintshile zihlobene nokubiquity, okuwuhlelo lokuwohloka kwamaprotheni oluhlobene ne-melanogenesis.
三．Spermidine ilawula ukuzinza kwamaprotheni futhi ikhuthaze ukukhiqizwa kwe-melanin.
Ukukhiqizwa kwe-melanin kulawulwa ukulingana kokuhlanganiswa kanye nokuwohloka kwamaprotheni ahlobene ne-melanin.I-Spermidine iphatha izakhi zofuzo ze-TYR, TRP-1 kanye ne-TRP-2.Ngesenzo sezakhi zofuzo ze-transporter SLC3A2, SLC7A1, SLC18B1 kanye ne-SLC22A18, ingakhuphula izinga lama-polyamines kumaseli, ngaleyo ndlela ikhulise ukuzinza kwamaprotheni ahlobene nokukhiqizwa kwe-melanin ukukhuthaza ukukhiqizwa kwe-melanin ku-vivo.
Ekuphetheni, lolu cwaningo lubonisa ukuthi i-spermidine ehlanganisiwe yemvelo inendima engaba khona ekwelapheni i-hypopigmentation, futhi inenani elithile lesicelo emkhakheni wezimonyo nemikhiqizo yezempilo esikhathini esizayo.
Ireferensi:
[1].Brito, S., Heo, H., Cha, B. et al.Ukuhlola okuhlelekile kuveza amandla e-spermidine ekwelapheni kwe-hypopigmentation ngokuzinzisa amaprotheni ahlobene ne-melanogenesis.Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Isikhathi sokuthumela: Sep-28-2022