Eminyakeni yamuva nje, ngokwanda kwezindlela zokuphila ezingaphilile kanye nokwanda kwengcindezi yomphakathi yabesifazane, izinga lokusabalala kwe-polycystic ovary syndrome (PCOS) liye lacaca kakhulu. Izifundo zakwamanye amazwe zibonise ukuthi ukwanda kwe-polycystic ovary syndrome (PCOS) kwabesifazane abaseminyakeni yokuzala kufinyelele ku-6% -15%, kanti eShayina, isilinganiso sifinyelela ku-6% -10%.
I-Polycystic ovary syndrome yisifo esivame ukwenzeka kwabesifazane abaneminyaka yokuzala ngenxa yezinkinga ze-endocrine. Ibonakala kakhulu ekusetshenzisweni kwe-glucose okungavamile kanye ne-lipid metabolism kanye nokungasebenzi kahle kokuzala. Izindlela zokuxilonga zemitholampilo ukuphazamiseka kwezinga lama-hormone (i-androgen ephezulu), ukuncipha kwezinkinga zokuvuthwa kanye nezinguquko ze-polycystic ze-ovarian, futhi iningi labesifazane abane-PC COS banezici ezimbi ze-metabolic, njengokumelana ne-insulin, ukukhuluphala ngokweqile, kanye ne-hepatic steatosis.
Njengamanje, kunemithi embalwa yokwelapha i-PCOS. Indlela evamile ukuthuthukisa i-PCOS ngokugxila nokuvimbela ukweqisa kwe-androgen ngemithi yokulwa ne-androgen. Kodwa-ke, kukhona nobufakazi bokuthi imithi yokulwa ne-androgen inobuthi obukhulu esibindini, ngakho-ke ukusetshenziswa kwayo kulinganiselwe. Ngakho-ke, kubaluleke kakhulu ukufuna into yemvelo engenamiphumela emibi ukuze ithathe indawo yemithi yamanje.
Ucwaningo lwamuva olwenziwe yi-University of New South Wales e-Australia luthole ukuthi i-polycystic ovary syndrome ihlobene nokuntuleka kwe-NAD+, futhi imiphumela yocwaningo yanyatheliswa kumagazini wesayensi i-“Molecular Metabolism”.
Ithimba locwaningo laqala ngokufaka i-dihydrotestosterone (DHT) ngaphansi kwesikhumba emagundwini abesifazane ngaphambi nangemva kokuthomba ukuze kusungulwe imodeli yegundane le-PC COS, kwathi ngemva kwamasonto ayi-8 okwelashwa kwe-NMN, i-insulin yokuzila ukudla kanye nokutholwa kokumelana ne-insulin ye-HOMA, ukuhlolwa kokubekezelela i-glucose, amafutha Ngemva kokuhlolwa okufana ne-histomorphometry, imiphumela yezibalo ikhombisa:
1. I-N MN ibuyisela izinga le-N AD + emisipheni yamagundane e-P COS
bathole ukuthi izinga le-NAD+ emisipheni yamagundane e-PCOS lehle kakhulu, kanti izinga le-NAD emisipheni yamagundane e-PCOS labuyiselwa ngokudla i-NMN.
2. I-NMN ithuthukisa ukumelana ne-insulin kanye nokukhuluphala emagundwini e-PCOS
Amazinga e-insulin abangelwa yi-DHT aphindwe kabili kumagundane e-PCOS azila ukudla, okungenzeka abonisa ukumelana ne-insulin. Ngokupha i-NMN ukudla, kwatholakala ukuthi izinga le-insulin elizila ukudla labuyiselwa ezingeni eliseduze nelamagundane avamile. Ngaphezu kwalokho, isisindo somzimba samagundane e-PCOS sanda ngo-20%, kanti isisindo samafutha sanda kakhulu.
3. I-NMN ibuyisela ukubekwa kwamafutha esibindini okungajwayelekile emagundwini e-PCOS
Esinye sezici ze-polycystic ovary syndrome ukubekwa kwamafutha esibindini kanye nokufakwa kwesibindi esinamafutha. Ngemva kokuthatha i-NMN, ukufakwa kwamafutha esibindini okungavamile emagundwini e-PCOS kwacishe kwaphela, futhi ama-triglycerides esibindini abuyela ezingeni lamagundane ajwayelekile.
Isiphetho, izinga le-NAD+ emisipheni ye-PCOS lancishiswa kakhulu, futhi isimo se-PCOS sancishiswa ngokunezela i-NMN, eyandulela i-NAD+, okungaba isu lokwelapha elingase libe khona lokwelapha i-PCOS.
izinkomba:
[1]. I-Aflatounian A, iParis VR, uRichani D, u-Edwards MC, uCochran BJ, uLedger WL, uGilchrist RB, uBertoldo MJ, uWu LE, uWalters KA. I-NAD+ yemisipha eyehlayo kumodeli yegundane le-PCOS ene-hyperandrogenism: Indima engaba khona ekuphazamisekeni kwe-metabolic. Mol Metab. 2022 Sep 9;65:101583. doi: 10.1016/j.molmet.2022.101583. I-Epub ngaphambi kokuphrinta. PMID: 36096453.
Isikhathi sokuthunyelwe: Novemba-17-2022