Eminyakeni yamuva, ngokwanda kwezindlela zokuphila ezingenampilo kanye nokucindezela komphakathi okwandayo kwabesifazane, izinga lokutholakala kwe-polycystic ovary syndrome (PCOS) liye laba sobala nakakhulu.Ucwaningo lwakwamanye amazwe lubonise ukuthi izehlakalo ze-polycystic ovary syndrome (PCOS) kwabesifazane abaneminyaka yobudala yokuzala ziphakeme kakhulu njenge-6% -15 %, kanti e-China, ingxenye iphezulu kakhulu njenge-6% -10 %.
I-Polycystic ovary syndrome yisifo esivame ukwenzeka kwabesifazane abaneminyaka yobudala ngenxa yokuphazamiseka kwe-endocrine.Ibonakaliswa ngokuyinhloko ku-glucose engavamile kanye ne-lipid metabolism kanye nokungasebenzi kahle kokuzala.Inqubo yokuxilonga emtholampilo iwukuphazamiseka kwezinga le-hormone (i-androgen ephezulu), enciphisa ukuphazamiseka kwe-Ovulation kanye nezinguquko ze-ovarian polycystic, futhi abesifazane abaningi abane-PC COS banezici ezingezinhle ze-metabolic, njengokumelana ne-insulin, ukukhuluphala, kanye ne-hepatic steatosis.
Njengamanje, kunezidakamizwa ezimbalwa zokwelashwa kwe-PCOS.Indlela evamile ukuthuthukisa i-PCOS ngokukhomba nokuvimbela ukweqisa kwe-androgen ngezidakamizwa ezilwa ne-androgen .Kodwa-ke, kukhona nobufakazi bokuthi izidakamizwa ezilwa ne-androgen zinobuthi obuqinile besibindi, ngakho ukusetshenziswa kwazo kunqunyelwe.Ngakho-ke, kubaluleke kakhulu ukufuna into yemvelo ngaphandle kwemiphumela emibi esikhundleni sezidakamizwa zamanje.
ucwaningo lwakamuva olwenziwe yiNyuvesi yaseNew South Wales e-Australia luthole ukuthi i-polycystic ovary syndrome ihlobene nokuntuleka kwe-NAD +, futhi imiphumela yocwaningo yanyatheliswa kumagazini wesayensi othi "Molecular Metabolism" .
Ithimba labacwaningi liqale lafaka i-dihydrotestosterone (DHT) ngaphansi kwesikhumba kumagundane abesifazane ngaphambi nangemva kokuthomba ukuze kusungulwe imodeli yegundane le-PC COS, bese kuthi ngemva kwamasonto angu-8 okwelashwa kwe-NMN, i-insulin yokuzila ukudla kanye nokutholwa kwe-HOMA ukumelana ne-insulin, ukuhlolwa kokubekezelela i-glucose, amafutha Ngemva kokuhlolwa okunjalo. njenge-histomorphometry, imiphumela yezibalo ibonisa:
1. I-N MN ibuyisela izinga le-N AD + kumsipha wamagundane e-P COS
ithole ukuthi izinga le-NAD+ kumsipha wamagundane e-PCOS lehle kakhulu, futhi izinga le-NAD kumsipha wamagundane e-PCOS labuyiselwa ngokuphakela kwe-NMN .
2. I-NMN ithuthukisa ukumelana ne-insulin nokukhuluphala kumagundane e-PCOS
Amazinga e-insulin enziwe nge-DHT angaphezu kokuphindwe kabili kumagundane e-PCOS azila ukudla, okungenzeka abonisa ukumelana ne-insulin.Ngokuphakela i-NMN, kwatholakala ukuthi izinga le-insulin yokuzila ukudla libuyiselwe ezingeni eliseduze nelamagundane avamile.Ngaphezu kwalokho, isisindo somzimba wamagundane e-PCOS senyuke ngo-20%, futhi isisindo samafutha sanda kakhulu.
3. I-NMN ibuyisela ukufakwa kwe-lipid ye-hepatic okungajwayelekile kumagundane e-PCOS
Esinye sezici ze-polycystic ovary syndrome ukwakheka kwe-lipid esibindini kanye nokufakwa kwesibindi esinamafutha.Ngemva kokuthatha i-NMN, ukufakwa okungavamile kwe-lipid kwesibindi kumagundane e-PCOS kwacishe kwaqedwa, futhi ama-triglycerides esibindi abuyela ezingeni lamagundane avamile.
isiphetho, izinga le-NAD+ kumsipha we-PCOS lancipha kakhulu, futhi isimo se-PCOS sancishiswa ngokufaka i-NMN, umanduleli we-NAD+, okungenzeka kube isu lokwelapha elingaba khona lokwelapha i-PCOS.
izinkomba:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Ukuncipha kwemisipha ye-NAD+ kumodeli yegundane ye-hyperandrogenism ye-PCOS: Indima engenzeka ekuphazamisekeni kwe-metabolic.I-Mol Metab.2022 Sep 9;65:101583.doi: 10.1016/j.molmet.2022.101583.I-Epub ngaphambi kokuphrinta.PMID: 36096453.
Isikhathi sokuthumela: Nov-17-2022