I-Triglyceride (TG) uhlobo lwamafutha olunokuqukethwe okukhulu emzimbeni womuntu. Zonke izitho nezicubu zomzimba womuntu zingasebenzisa i-triglyceride ukunikeza amandla, futhi isibindi singakhiqiza i-triglyceride futhi siyigcine esibindini. Uma i-triglyceride ikhuphuka, kusho ukuthi isibindi siqoqa amafutha amaningi kakhulu, okuyisibindi esinamafutha. I-Triglyceride uhlobo lwe-hyperlipidemia, futhi umonakalo wayo omkhulu emzimbeni womuntu ukubangela i-atherosclerosis, ukuvaleka kwemithambo yegazi kanye ne-thrombosis. Ngaphezu kwalokho, izifundo zikhombisile ukuthi ama-triglyceride aphezulu angabangela nomfutho wegazi ophakeme, amatshe enyongo, i-pancreatitis, isifo se-Alzheimer nokunye.
Ucwaningo lwamuva nje lwezokwelapha kubantu eJapane luphinde lwafakazela izinzuzo ze-NMN emzimbeni womuntu. Ngokusebenzisa izivivinyo zezokwelapha zabantu, ithimba locwaningo lifakazele ukuthi ukujova nge-NMN ngemithambo yegazi kuphephile emzimbeni womuntu, okungeke nje kwandise kakhulu izinga le-NAD+ egazini, kodwa futhi kunciphisa kakhulu izinga le-triglyceride egazini ngaphandle kokulimaza amaseli egazi.
Ithimba locwaningo liqashe abantu abayi-10 abanempilo (abesilisa abayi-5 nabesifazane abayi-5, abaneminyaka engu-20 kuya ku-70). Ngemva kokuzila ukudla amahora ayi-12, ama-300mg e-NMN ancibilikiswa ku-100mL saline futhi afakwa kubantu abavolontiya ngemithambo yengalo (5mL/min). Ama-X-ray esifubeni athathwe ngaphambi nangemva komjovo we-NMN, futhi kwalinganiswa isisindo, izinga lokushisa, umfutho wegazi, ukushaya kwenhliziyo kanye nokugcwala komoya-mpilo egazini. Igazi nomchamo kwaqoqwa ukuze kuhlolwe. Ngokuhlaziywa okuqhathanisayo kwemiphumela eminingi yokuhlolwa, kutholakale ukuthi izimpawu eziyinhloko zesibindi, ama-pancreas, inhliziyo nezinso azinazo izinguquko ezisobala, futhi ngaphezu kwalokho, ngeke zithinte izimpawu eziyinhloko zamaseli abomvu egazi, amaseli amhlophe egazi nama-platelet egazini, futhi ababambiqhaza abanazo izimpendulo ezimbi.
Kubalulekile ukuqaphela ukuthi izinga le-triglyceride egazini lishintshe ngokusobala. Ngemva kokuba abantu bethole umjovo we-NMN isigamu sehora, izinga le-triglyceride lehla ngokusobala, kwaze kwaba ngemva kwamahora ama-5, nakuba kwakukhona ukuthambekela okuncane kokululama, lo mehluko omkhulu wawusekhona.
Kusukela ekuhlolweni kwezilwane ngaphambi kokuhlolwa kuya ekuhlolweni kwezokwelapha kwabantu, izinzuzo ze-NMN emzimbeni womuntu ziqinisekiswe ngempumelelo. Lolu cwaningo lwezokwelapha lwabantu lufakazela umsebenzi we-NMN ekunciphiseni i-triglyceride, okuyizindaba ezinhle kubantu abakhuluphele nabagugayo.
Izinkomba:
[1]. Kimura S, Ichikawa M, Sugawara S, et al. (Septhemba 05, 2022) I-Nicotinamide Mononucleotide Iguqulwa Ngokuphephile Futhi Yehlisa Ngokuphawulekayo Amazinga E-Triglyceride Egazini Kubantu Abaphilile. I-Cureus 14(9): e28812. doi:10.7759/cureus.28812
Isikhathi sokuthunyelwe: Novemba-11-2022