I-β-Nicotinamide Mononucleotide (NMN)
Muva nje, kunezindaba ezinhle emkhakheni we-NMN - ngemuva kokubuyekezwa okuqinile yikomidi lochwepheshe lenhlangano enegunya le-US Food and Drug Administration (FDA), izinto zokusetshenziswa ze-NMN ze-Shangke Biopharmaceutical (Shanghai) Co., Ltd. (ezizobizwa ngokuthi "i-Shangke Bio") zivunyiwe yi-United States. Ukuvunyelwa kwe-FDA NDI kuqinisekisa ukuthi izinto zayo zokusetshenziswa ze-NMN zingasetshenziswa ngokusemthethweni ekukhiqizweni, ekuthengisweni nasekukhuthazeni izithasiselo zokudla e-United States, futhi zingatholakala kuwebhusayithi esemthethweni ye-FDA njengezinto zokusetshenziswa ezintsha zokusetshenziswa, inombolo 1247.
I-FDA NDI uhlelo lokuqinisekisa olubaluleke kakhulu emakethe yase-US. Ukuthola lesi sitifiketi akusho nje kuphela ukuthi ukuphepha nekhwalithi yemikhiqizo ye-Shangke Biokuyaqashelwa kakhulu, kodwa futhi kuyasiza ekuthuthukisweni okuqhubekayo okujwayelekile kwemboni ye-NMN ngokuhamba kwesikhathi.
| Igama Lekhemikhali | i-β-Nicotinamide Mononucleotide |
| Amagama afanayo | I-NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE |
| Inombolo ye-CAS | 1094-61-7 |
| Isisindo sama-molecule | 334.22 |
| Ifomula Yamamolekyuli | C11H15N2O8P |
| I-EINECS: | 214-136-5 |
| Indawo yokuncibilika | 166 °C(Disemba) |
| izinga lokushisa lokugcina. | -20°C |
| ukuncibilika | I-DMSO (Kancane, Ifudumele), I-Methanol (Kancane), Amanzi (Kancane) |
| ifomu | Okuqinile |
| umbala | Okumhlophe kuya Kophuzi |
| I-Merck | 13,6697 |
| I-BRN | 3570187 |
| Ukuzinza: | I-Hygroscopic kakhulu |
| I-InChIKey | I-DAYLJWODMCOQEW-TURQNECASA-N |
| Into Yokuhlola | Imininingwane |
| Ukubukeka | Impuphu yekristalu emhlophe kuya kwemhlophe kakhulu |
| Okuqukethwe kwe-sodium | ≤1% |
| Inani le-pH (100mg/ml) | 2.0~4.0 |
| Ubumsulwa | ≥99.0% |
| Okuqukethwe kwamanzi | ≤1% |
| Izinsimbi ezisindayo | <10ppm |
| I-Arsenic | <0.5ppm |
| Umholi | <0.5ppm |
| I-Mercury | <0.1ppm |
| I-Cadmium | <0.5ppm |
| Izinsalela ze-solvent | I-Ethanol≤1000ppm |
| Inani Eliphelele Lama-Microbial Aerobic | <750cfu/g |
| Imvubelo Nokukhunta | <25cfu/g |
| I-coliform ephelele | ≤0.92MPN/g |
| E. Coli | Okubi |
| I-Salmonella | Okubi |
| UStaph. Aureus | Okubi |
| Ukuhlolwa (ngokusekelwe ku-anhydrous) | ≥99.0% |
| Izinga lokucwila | ≥95% |
| Ubuningi obukhulu | Bika ukuze uthole ulwazi |
Iphakheji:Ibhodlela, isikhwama sefoyile ye-aluminium, i-25kg/i-Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sokugcina:Gcina ezitsheni eziqinile, ezingangeni ukukhanya, ukuze zigcinwe isikhathi eside, zigcine ku-2 ~ 8°C noma ngaphansi.
I-Nicotinamide Mononucleotide (NMN) inguqulo entsha ye-vitamin B3 eyisinyathelo sokuqala sokuqala se-NAD+ (Nicotinamide Adenine Dinucleotide). I-NMN ingumlungisi wokuqala we-NAD+ weseli ofakazelwe ukuthi uyasebenza ekubuyiseleni amaseli emzimbeni.
I-Nicotinamide Adenine Dinucleotide (NAD) ingenye yama-molecule abaluleke kakhulu futhi athakazelisayo emzimbeni. Iyadingeka ekuphenduleni kwama-enzyme angaphezu kuka-500 futhi idlala indima ebalulekile ekulawulweni cishe kwazo zonke izinqubo ezinkulu zebhayoloji (u-Ansari no-Raghava, 2010). Ngaphezu kwakho konke, ingasivumela ukuthi siphile impilo enempilo nende.
I-Nicotinamide Adenine Dinucleotide (NAD) ikhona ngesimo sayo esihlanganisiwe (NAD+) noma ngesimo esincishisiwe (NADH), okuyizinto ezibalulekile ezihlanganisa ama-oxireductase amaningi.
I-SyncoZyems njengenkampani yokuqala yokuthola inkampani yokukhiqiza izinto zokusetshenziswa ezivunyiwe yi-FDA NDI NMN, imele isikhulu se-FDA esamukela i-NMN njengohlobo olusha lwezinto ezingasetshenziswa ukwamukelwa futhi zivunyelwe izithako zezithako zokudla e-United States.
