Ngomhlaka-14 Okthoba 2020, umbukiso wama-85 we-China International Pharmaceutical API/Intermediate/Packaging/Equipment Fair (obizwa ngokuthi i-API China API) wavulwa eNanjing International Expo Center. I-Shangke Bio kanye ne-Zhejiang Supor Pharmaceutical Co., Ltd. bahlanganyele eMbukisweni we-API we-Nanjing API CHINA ka-2020. UDkt. Zhu, uMphathi Jikelele we-Shangke Biology, wenze umbiko okhethekile wezemfundo mayelana "nesikhathi esidlule, samanje nesesikhathi esizayo se-NMN" embukisweni.
Izithombe zesixuku sombukiso
Kulo mbukiso, iShangke Bio izobonisa i-coenzyme NMN, NAD, NADH, NADP, NADPH, ama-enzyme ebhayoloji, ama-API, ama-intermediate kanye neminye imikhiqizo, futhi ibe nokuxhumana okujulile nabangani abavela kulo lonke izwe.
Izithombe zombiko wezemfundo
Ngesikhathi sombukiso, i-8th Vitamin Special Day of Health.com yaqhutshwa ngempumelelo. UDkt. Zhu, uMphathi Jikelele weShangke Biotechnology, wamenywa ukuba ahlanganyele kulo mcimbi futhi wanikeza inkulumo ngesihloko esithi "Isikhathi Esidlule, Samanje Nesizayo se-NMN". Okuqukethwe kwenkulumo kwahlonishwa kakhulu ngabantu abangaphakathi embonini. Ukuqashelwa nokuqashelwa okuphezulu kwempendulo enomdlandla. Umphumela wokulwa nokuguga we-NMN uqinisekiswe ngokwesayensi futhi usekelwa yizimo eziningi zangempela. Umbiko wezemfundo we-NMN esizeni uphinde wadonsela ukunaka kwabathengi namakhasimende amaningi.
UDkt. Zhu wethule inkulumo evela ekuthuthukisweni kwe-NMN, futhi kancane kancane wembula imfihlakalo yomuthi wokulwa nokuguga i-NMN: I-NMN ifushaniswe ngokuthi i-β-nicotinamide mononucleotide, okuyisandulelo se-NAD+; iziphetho ezifanele zokuhlola ezanyatheliswa ochungechungeni lwezincwadi zesayensi eziphezulu zomhlaba wonke zifakazela ukuthi, ikholelwa ukuthi okuqukethwe yi-NAD+ emzimbeni womuntu kwehla ngokuguga, okuholela ekugugeni kusukela eminyakeni engu-30, ngemibimbi, ukuphumula kwemisipha, ukuqongelela kwamafutha, kanye nengozi eyengeziwe yesifo senhliziyo, umfutho wegazi ophakeme, isifo sohlangothi, isifo sikashukela, kanye nesifo i-Alzheimer's. Ucwaningo luthole ukuthi lapho amangqamuzana ephansi ku-NAD+, asabela ngokuveza okuningi kwe-SLC12A8 transporter, okuvumela ukumuncwa okuphumelelayo kwe-NMN egazini, kuyilapho i-SLC12A8 transporter gene itholakale ibonakaliswa ezicutshini eziningi nasemathunjini. Okuqukethwe okusemzimbeni kuphezulu kakhulu. Emathunjini, i-NMN imuncwa ngokushesha emathunjini amancane kungakapheli imizuzu engu-2-3 futhi iguqulwe ibe yi-NAD+ kungakapheli imizuzu eyi-10-30.
Umphumela wokulwa nokuguga we-NMN uqinisekiswe ngokwesayensi futhi usekelwa yizimo eziningi zangempela. Njengamanje, iJapane isibe yizwe elivumile ngokusemthethweni i-NMN njengezinto zokudla eziluhlaza.
NgoJanuwari 2019, i-NMN yayinemikhiqizo engu-188 kuphela kuyo yonke inethiwekhi, kwathi ekupheleni kuka-Agasti 2020, inani lemikhiqizo kuyo yonke inethiwekhi yasekhaya lase lidlule ku-2,962. Kukhona ukwanda kwemikhiqizo, ukuntuleka kwezindinganiso zemboni, kanye nokuntuleka kokucatshangelwa kokuphepha nokusebenza kahle. Ngaphezu kwalokho, izinhlobo eziningi ze-NMN azinawo ubuchwepheshe obuyinhloko, futhi imikhiqizo ixubile.
Imakethe yemikhiqizo yokulwa nokuguga emhlabeni wonke (kufaka phakathi izigaba ezintathu zemikhiqizo yokunakekelwa kwezimonyo, ukudla kanye nemikhiqizo yokulwa nokuguga yemithi) yalinganiselwa ku-US$250 billion ngo-2016 futhi kulindeleke ukuthi ikhule ku-CAGR engu-5.8% ifinyelele ku-US$331.41 billion ngo-2021. INyakatho Melika njengamanje iyisifunda esihamba phambili emakethe yokulwa nokuguga emhlabeni wonke, ilandelwe yiYurophu neJapan, kanti i-Asia Pacific kulindeleke ukuthi ibe yisifunda esikhula ngokushesha emhlabeni esikhathini esizayo. Njengamanje, abahlinzeki bezinto zokusetshenziswa komhlaba wonke be-NMN bagxile kakhulu eShayina, futhi izinqubo zokukhiqiza zifaka phakathi ukwakheka kwamakhemikhali, ukwakheka kwamakhemikhali-enzymatic kanye nendlela ephelele ye-enzymatic. Ucwaningo lwezokwelapha olwanele ngemisebenzi efanele ye-NMN luyisisekelo sokukhula kwemakethe yesikhathi esizayo, futhi ukuthobela umthetho kanye nendawo kuyizinto ezibalulekile zokuthuthukiswa kwemakethe yesikhathi esizayo. I-Coenzyme idlala indima ebalulekile enkambisweni ye-metabolism yomzimba womuntu, futhi imikhiqizo yayo isetshenziswa kabanzi embonini yokudla nemikhiqizo yezempilo. Ngaphezu kwalokho, i-coenzyme iyinto eluhlaza eyinhloko ye-biopharmaceuticals eluhlaza.
I-Shangke Bio yibhizinisi eliqaphela ukukhiqizwa kwe-coenzyme NMN/NAD/NADH/NADP/NADPH ngezinga lezimboni kanye neminye imikhiqizo ngokusebenzisa ubuchwepheshe be-enzyme catalysis, futhi selidlulile isitifiketi sesistimu yokuphathwa kwekhwalithi ye-ISO9001, i-SELF GRAS (i-US FDA ihlola inkomba yokuphepha kwezithasiselo zokudla) kanye nesitifiketi sokuqinisekisa esithi "acute oral toxicity test" kuzuze idumela elihle embonini, futhi imikhiqizo ithunyelwa emhlabeni wonke.
Isikhathi sokuthunyelwe: Okthoba-28-2020