I-NMN yehlisa i-radiation-induced intestinal fibrosis ngokumodulating gut microbiota

I-intestinal fibrosis ebangelwa ukukhishwa kwemisebe iyinkinga evamile yabantu abaphila isikhathi eside ngemva kokwelashwa nge-radiation yesisu kanye ne-pelvic.Njengamanje, ayikho indlela etholakala emtholampilo yokwelapha i-radiation-indused intestinal fibrosis.Ucwaningo luye lwabonisa ukuthi i-nicotinamide mononucleotide (NMN) inamandla okulawula izitshalo zamathumbu.Izitshalo zamathumbu ziyi-microorganism evamile emathunjini omuntu, engahlanganisa izakhi ezihlukahlukene ezidingekayo ekukhuleni nasekuthuthukeni komuntu.Uma i-flora yamathumbu ingalingani, izobangela izifo ezihlukahlukene.
Muva nje, i-China Academy of Medical Sciences kanye ne-Peking Union Medical College ishicilele imiphumela yocwaningo kumagazini i-International Journal of Radiation Biology, eyabonisa ukuthi i-NMN inganciphisa i-intestinal fibrosis ebangelwa imisebe ngokulawula izitshalo zamathumbu.
Ekuqaleni, ithimba locwaningo lahlukanisa amagundane ngeqembu elilawulayo, iqembu le-NMN, iqembu le-IR kanye neqembu le-NMNIR, futhi lanikeza imisebe yesisu eyi-15 Gy eqenjini le-IR kanye neqembu le-NMNIR.Ngaleso sikhathi, isithasiselo se-NMN sanikezwa iqembu le-NMN neqembu le-NMNIR ngedosi yansuku zonke engu-300mg/kg.Ngemuva kokuyithatha isikhathi esithile, ngokuthola indle yegundane, i-microflora yamathumbu kanye nezimpawu zezicubu ze-colon, imiphumela yokuqhathanisa ibonise ukuthi:

1. I-NMN ingalungisa ukwakheka nokusebenza kwezitshalo zamathumbu eziphazanyiswa imisebe.
Ngokuqhathanisa ukutholwa kwezitshalo zamathumbu phakathi kweqembu le-IR neqembu le-NMNIR, kutholakale ukuthi amagundane eqembu le-IR andise ukuchichima kwezitshalo zamathumbu eziyingozi, njengeLactobacillus du, Bacillus faecalis, njll. Ngokumangalisayo, amagundane eqembu le-NMNIR aguqule ukuhlukahluka kwezitshalo zamathumbu. futhi kwandise ukuchichima kwezitshalo zamathumbu ezizuzisayo, njengamabhaktheriya e-AKK, ​​ngokufaka i-NMN.Ukuhlola kubonisa ukuthi i-NMN ingalungisa ukwakheka nokusebenza kwezitshalo zamathumbu ezingasebenzi kahle ngenxa yemisebe.

2. I-NMN inciphisa i-intestinal fibrosis ebangelwa imisebe
Izinga le-aSMA (Fibrosis Marker) kumagundane avezwe emisebeni lenyuke kakhulu.Ngemuva kokuxhaswa kwe-NMN, hhayi kuphela izinga le-aSMA marker lehla kakhulu, kodwa futhi isici esivuthayo se-TGF-b esakhuthaza i-intestinal fibrosis sehle kakhulu, okubonisa ukuthi ukwesekwa kwe-NMN kunganciphisa i-intestinal fibrosis ebangelwa imisebe.

(Umfanekiso 1. Ukwelashwa kwe-NMN kunciphisa i-intestinal fibrosis ebangelwa imisebe)

Ngaphansi kwesizinda sokusabalala kwemikhiqizo ye-elekthronikhi, imisebe inomthelela okhulayo emsebenzini nokuphila kwabantu, ikakhulukazi ezimbali zamathumbu isikhathi eside.I-NMN inomthelela oqinile wokuvikela empilweni yamathumbu.Lo mphumela awutholakali kuphela ngento eyodwa noma indlela ethile, kodwa futhi ngokulawula isakhiwo sokusabalalisa sezitshalo ukukhuthaza ukuzinza komsebenzi wamathumbu kusuka kuma-engeli ahlukahlukene kanye nezikhombisi-ndlela, okubuye kunikeze ireferensi ebalulekile yezinzuzo ezihlukahlukene ze-NMN.

Izithenjwa:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): I-NMN yehlisa i-radiation-induced intestinal fibrosis ngokumodulating gut microbiota, International Journal of Radiation Biology, DOI: 10.10450292.