I-fibrosis yamathumbu ebangelwa imisebe iyinkinga evamile yabantu abasindile isikhathi eside ngemva kokwelashwa ngemisebe esiswini nangasesinqeni. Njengamanje, ayikho indlela etholakalayo yokwelapha i-fibrosis yamathumbu ebangelwa imisebe. Izifundo zikhombisile ukuthi i-nicotinamide mononucleotide (NMN) inamandla okulawula izitshalo zamathumbu. Izitshalo zamathumbu ziyi-microorganism evamile emathunjini omuntu, engakwazi ukukhiqiza izakhamzimba ezahlukahlukene ezidingekayo ekukhuleni nasekuthuthukisweni komuntu. Uma izitshalo zamathumbu zingalingani, zizobangela izifo ezahlukahlukene.
Muva nje, i-China Academy of Medical Sciences kanye ne-Peking Union Medical College bashicilele imiphumela yocwaningo ephephabhukwini i-International Journal of Radiation Biology, ebonise ukuthi i-NMN inganciphisa i-fibrosis yamathumbu ebangelwa imisebe ngokulawula izitshalo zamathumbu.
Ekuqaleni, ithimba locwaningo lahlukanisa amagundane ngeqembu lokulawula, iqembu le-NMN, iqembu le-IR kanye neqembu le-NMNIR, futhi lanikeza i-IR kanye neqembu le-NMNIR imisebe engu-15 yesisu. Phakathi naleso sikhathi, isithasiselo se-NMN sanikezwa iqembu le-NMN kanye neqembu le-NMNIR ngomthamo wansuku zonke ongu-300mg/kg. Ngemva kokusithatha isikhathi esithile, ngokuthola indle yegundane, i-microflora yamathumbu kanye nezimpawu zezicubu zamathumbu, imiphumela yokuqhathanisa ibonise ukuthi:
1. I-NMN ingalungisa ukwakheka kanye nomsebenzi wezitshalo zamathumbu eziphazanyiswa imisebe.
Ngokuqhathanisa ukutholakala kwezitshalo zamathumbu phakathi kweqembu le-IR neqembu le-NMNIR, kwatholakala ukuthi amagundane eqembu le-IR andise inqwaba yezitshalo zamathumbu eziyingozi, njenge-Lactobacillus du, i-Bacillus faecalis, njll. Ngokumangazayo, amagundane eqembu le-NMNIR ashintshe ukuhlukahluka kwezitshalo zamathumbu futhi andise inqwaba yezitshalo zamathumbu eziwusizo, njengebhaktheriya le-AKK, ngokufaka i-NMN. Ukuhlolwa kubonisa ukuthi i-NMN ingalungisa ukwakheka kanye nomsebenzi wezitshalo zamathumbu okungalingani ngenxa yemisebe.
2. I-NMN inciphisa i-fibrosis yamathumbu ebangelwa imisebe
Izinga le-aSMA (Fibrosis Marker) emagundwini abhekene nemisebe landa kakhulu. Ngemva kokwengezwa kwe-NMN, akulona nje kuphela izinga lophawu lwe-aSMA elehle kakhulu, kodwa futhi nesici sokuvuvukala i-TGF-b esasikhuthaza i-intestinal fibrosis sehle kakhulu, okubonisa ukuthi ukwengezwa kwe-NMN kunganciphisa i-intestinal fibrosis ebangelwa imisebe.
(Isithombe 1. Ukwelashwa kwe-NMN kunciphisa i-fibrosis yamathumbu ebangelwa imisebe)
Ngaphansi kwesizinda sokusabalala kwemikhiqizo kagesi, imisebe inomthelela okhulayo emsebenzini nasekuphileni kwabantu, ikakhulukazi ezitshalweni zamathumbu isikhathi eside. I-NMN inomthelela oqinile wokuvikela empilweni yamathumbu. Lo mphumela awugcini nje ngokutholakala ngento eyodwa noma ngendlela ethile, kodwa futhi nokulawula isakhiwo sokusatshalaliswa kwezitshalo ukuze kukhuthazwe ukuzinza komsebenzi wamathumbu kusuka ezinhlangothini naseziqondisweni ezahlukahlukene, okunikeza nenkomba ebalulekile yezinzuzo ezahlukahlukene ze-NMN.
Izinkomba:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): I-NMN yehlisa i-radiation-induced intestinal fibrosis ngokumodulating gut microbiota, International Journal of Radiation Biology, DOI: 10.10450292.
Isikhathi sokuthunyelwe: Disemba-08-2022